Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their...

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Detalles Bibliográficos
Autores principales: Hou, Xue-Qin, Wang, Lei, Wang, Fu-Gang, Zhao, Xiao-Min, Zhang, Han-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448009/
https://www.ncbi.nlm.nih.gov/pubmed/28481269
http://dx.doi.org/10.3390/genes8050135
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author Hou, Xue-Qin
Wang, Lei
Wang, Fu-Gang
Zhao, Xiao-Min
Zhang, Han-Ting
author_facet Hou, Xue-Qin
Wang, Lei
Wang, Fu-Gang
Zhao, Xiao-Min
Zhang, Han-Ting
author_sort Hou, Xue-Qin
collection PubMed
description RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.
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spelling pubmed-54480092017-05-30 Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases Hou, Xue-Qin Wang, Lei Wang, Fu-Gang Zhao, Xiao-Min Zhang, Han-Ting Genes (Basel) Review RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases. MDPI 2017-05-06 /pmc/articles/PMC5448009/ /pubmed/28481269 http://dx.doi.org/10.3390/genes8050135 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hou, Xue-Qin
Wang, Lei
Wang, Fu-Gang
Zhao, Xiao-Min
Zhang, Han-Ting
Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
title Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
title_full Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
title_fullStr Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
title_full_unstemmed Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
title_short Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
title_sort combination of rna interference and stem cells for treatment of central nervous system diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448009/
https://www.ncbi.nlm.nih.gov/pubmed/28481269
http://dx.doi.org/10.3390/genes8050135
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