Cargando…
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current t...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448155/ https://www.ncbi.nlm.nih.gov/pubmed/28593025 http://dx.doi.org/10.1155/2017/4134093 |
_version_ | 1783239515151794176 |
---|---|
author | Fardoun, Manal Al-Shehabi, Tuqa El-Yazbi, Ahmed Issa, Khodr Zouein, Fouad Maaliki, Dina Iratni, Rabah Eid, Ali H. |
author_facet | Fardoun, Manal Al-Shehabi, Tuqa El-Yazbi, Ahmed Issa, Khodr Zouein, Fouad Maaliki, Dina Iratni, Rabah Eid, Ali H. |
author_sort | Fardoun, Manal |
collection | PubMed |
description | Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current treatments for atherosclerosis remain insufficient, prompting the search for alternative modalities, including herbal medicine. Ziziphus nummularia is an herb commonly used in the amelioration of symptoms associated with many health conditions such as cold, diarrhea, cancer, and diabetes. However, its effect on the inflammation-induced behavior of VSMCs remains unknown. In this study, we sought to determine the effect of the ethanolic extract of Z. nummularia (ZNE) on TNF-α-induced phenotypic changes of human aortic smooth muscle cells (HASMCs). The treatment of HASMCs with ZNE decreased cell proliferation, adhesion to fibronectin, migration, and invasion. ZNE treatment also caused a concentration- and time-dependent reduction in the TNF-α-induced expression of matrix metalloproteases MMP-2 and MMP-9, NF-κB, and cell adhesion molecules ICAM-1 and VCAM-1. Furthermore, ZNE decreased the adhesion of THP-1 monocytes to HASMCs and endothelial cells in a concentration-dependent manner. These data provide evidence for the anti-inflammatory effect of Ziziphus nummularia, along with potential implications for its use as an agent that could ameliorate inflammation-induced atherogenic phenotype of VSMCs in atherosclerosis. |
format | Online Article Text |
id | pubmed-5448155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54481552017-06-07 Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells Fardoun, Manal Al-Shehabi, Tuqa El-Yazbi, Ahmed Issa, Khodr Zouein, Fouad Maaliki, Dina Iratni, Rabah Eid, Ali H. Oxid Med Cell Longev Research Article Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current treatments for atherosclerosis remain insufficient, prompting the search for alternative modalities, including herbal medicine. Ziziphus nummularia is an herb commonly used in the amelioration of symptoms associated with many health conditions such as cold, diarrhea, cancer, and diabetes. However, its effect on the inflammation-induced behavior of VSMCs remains unknown. In this study, we sought to determine the effect of the ethanolic extract of Z. nummularia (ZNE) on TNF-α-induced phenotypic changes of human aortic smooth muscle cells (HASMCs). The treatment of HASMCs with ZNE decreased cell proliferation, adhesion to fibronectin, migration, and invasion. ZNE treatment also caused a concentration- and time-dependent reduction in the TNF-α-induced expression of matrix metalloproteases MMP-2 and MMP-9, NF-κB, and cell adhesion molecules ICAM-1 and VCAM-1. Furthermore, ZNE decreased the adhesion of THP-1 monocytes to HASMCs and endothelial cells in a concentration-dependent manner. These data provide evidence for the anti-inflammatory effect of Ziziphus nummularia, along with potential implications for its use as an agent that could ameliorate inflammation-induced atherogenic phenotype of VSMCs in atherosclerosis. Hindawi 2017 2017-05-15 /pmc/articles/PMC5448155/ /pubmed/28593025 http://dx.doi.org/10.1155/2017/4134093 Text en Copyright © 2017 Manal Fardoun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Fardoun, Manal Al-Shehabi, Tuqa El-Yazbi, Ahmed Issa, Khodr Zouein, Fouad Maaliki, Dina Iratni, Rabah Eid, Ali H. Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells |
title |
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells |
title_full |
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells |
title_fullStr |
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells |
title_full_unstemmed |
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells |
title_short |
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells |
title_sort | ziziphus nummularia inhibits inflammation-induced atherogenic phenotype of human aortic smooth muscle cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448155/ https://www.ncbi.nlm.nih.gov/pubmed/28593025 http://dx.doi.org/10.1155/2017/4134093 |
work_keys_str_mv | AT fardounmanal ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT alshehabituqa ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT elyazbiahmed ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT issakhodr ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT zoueinfouad ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT maalikidina ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT iratnirabah ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells AT eidalih ziziphusnummulariainhibitsinflammationinducedatherogenicphenotypeofhumanaorticsmoothmusclecells |