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Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity

The detection of KRAS and BRAF mutations is a crucial step for the correct therapeutic approach and predicting the epidermal growth factor receptor (EGFR)-targeted therapy resistance of colorectal carcinomas. The concomitant KRAS and BRAF mutations occur rarely in the colorectal cancers (CRCs) with...

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Autores principales: Larki, Pegah, Gharib, Ehsan, Yaghoob Taleghani, Mohammad, Khorshidi, Fatemeh, Nazemalhosseini-Mojarad, Ehsan, Asadzadeh Aghdaei, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448326/
https://www.ncbi.nlm.nih.gov/pubmed/28580315
http://dx.doi.org/10.22074/cellj.2017.5123
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author Larki, Pegah
Gharib, Ehsan
Yaghoob Taleghani, Mohammad
Khorshidi, Fatemeh
Nazemalhosseini-Mojarad, Ehsan
Asadzadeh Aghdaei, Hamid
author_facet Larki, Pegah
Gharib, Ehsan
Yaghoob Taleghani, Mohammad
Khorshidi, Fatemeh
Nazemalhosseini-Mojarad, Ehsan
Asadzadeh Aghdaei, Hamid
author_sort Larki, Pegah
collection PubMed
description The detection of KRAS and BRAF mutations is a crucial step for the correct therapeutic approach and predicting the epidermal growth factor receptor (EGFR)-targeted therapy resistance of colorectal carcinomas. The concomitant KRAS and BRAF mutations occur rarely in the colorectal cancers (CRCs) with the prevalence of less than 0.001% of the cases. In patients with KRAS-mutant tumors, BRAF mutations should not regularly be tested unless the patient is participating in a clinical trial enriching for the presence of KRAS or BRAF-mutated tumor. The current report demonstrates a case with advanced adenocarcinoma of the colon showing the coexistence of KRAS and BRAF mutations and may have profound clinical implications for disease progression and therapeutic responses.
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spelling pubmed-54483262017-06-02 Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity Larki, Pegah Gharib, Ehsan Yaghoob Taleghani, Mohammad Khorshidi, Fatemeh Nazemalhosseini-Mojarad, Ehsan Asadzadeh Aghdaei, Hamid Cell J Case Report The detection of KRAS and BRAF mutations is a crucial step for the correct therapeutic approach and predicting the epidermal growth factor receptor (EGFR)-targeted therapy resistance of colorectal carcinomas. The concomitant KRAS and BRAF mutations occur rarely in the colorectal cancers (CRCs) with the prevalence of less than 0.001% of the cases. In patients with KRAS-mutant tumors, BRAF mutations should not regularly be tested unless the patient is participating in a clinical trial enriching for the presence of KRAS or BRAF-mutated tumor. The current report demonstrates a case with advanced adenocarcinoma of the colon showing the coexistence of KRAS and BRAF mutations and may have profound clinical implications for disease progression and therapeutic responses. Royan Institute 2017 2017-05-17 /pmc/articles/PMC5448326/ /pubmed/28580315 http://dx.doi.org/10.22074/cellj.2017.5123 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Larki, Pegah
Gharib, Ehsan
Yaghoob Taleghani, Mohammad
Khorshidi, Fatemeh
Nazemalhosseini-Mojarad, Ehsan
Asadzadeh Aghdaei, Hamid
Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity
title Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity
title_full Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity
title_fullStr Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity
title_full_unstemmed Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity
title_short Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity
title_sort coexistence of kras and braf mutations in colorectal cancer: a case report supporting the concept of tumoral heterogeneity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448326/
https://www.ncbi.nlm.nih.gov/pubmed/28580315
http://dx.doi.org/10.22074/cellj.2017.5123
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