Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells

We have demonstrated that simvastatin and sphingosine 1−phosphate (S1P) both attenuate increased vascular permeability in preclinical models of acute respiratory distress syndrome. However, the underlying mechanisms remain unclear. As Krüppel-like factor 2 (KLF2) serves as a critical regulator for c...

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Detalles Bibliográficos
Autores principales: Sun, Xiaoguang, Mathew, Biji, Sammani, Saad, Jacobson, Jeffrey R., Garcia, Joe G. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448536/
https://www.ncbi.nlm.nih.gov/pubmed/28680571
http://dx.doi.org/10.1177/2045893217701162

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