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Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan
We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (i) histologically proven bone sarcomas of the skull base or spine; (ii) no metastases; (iii) ≥20...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448607/ https://www.ncbi.nlm.nih.gov/pubmed/28182320 http://dx.doi.org/10.1111/cas.13192 |
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author | Demizu, Yusuke Mizumoto, Masashi Onoe, Tsuyoshi Nakamura, Naoki Kikuchi, Yasuhiro Shibata, Tetsushi Okimoto, Tomoaki Sakurai, Hideyuki Akimoto, Tetsuo Ono, Kota Daimon, Takashi Murayama, Shigeyuki |
author_facet | Demizu, Yusuke Mizumoto, Masashi Onoe, Tsuyoshi Nakamura, Naoki Kikuchi, Yasuhiro Shibata, Tetsushi Okimoto, Tomoaki Sakurai, Hideyuki Akimoto, Tetsuo Ono, Kota Daimon, Takashi Murayama, Shigeyuki |
author_sort | Demizu, Yusuke |
collection | PubMed |
description | We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (i) histologically proven bone sarcomas of the skull base or spine; (ii) no metastases; (iii) ≥20 years of age; and (iv) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed‐up for >6 months or had died within 6 months. Seventy‐two patients (75.0%) had chordoma, 20 patients (20.8%) had chondrosarcoma, and four patients (7.2%) had osteosarcoma. The most frequent tumor locations included the skull base in 68 patients (70.8%) and the sacral spine in 13 patients (13.5%). Patients received a median total dose of 70.0 Gy (relative biological effectiveness). The median follow‐up was 52.6 (range, 6.3–131.9) months. The 5‐year overall survival, progression‐free survival, and local control rates were 75.3%, 49.6%, and 71.1%, respectively. Performance status was a significant factor for overall survival and progression‐free survival, whilst sex was a significant factor for local control. Acute Grade 3 and late toxicities of ≥Grade 3 were observed in nine patients (9.4%) each (late Grade 4 toxicities [n = 3 patients; 3.1%]). No treatment‐related deaths occurred. Proton beam therapy is safe and effective for the treatment of bone sarcomas of the skull base and spine in Japan. However, larger prospective studies with a longer follow‐up are warranted. |
format | Online Article Text |
id | pubmed-5448607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54486072017-06-01 Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan Demizu, Yusuke Mizumoto, Masashi Onoe, Tsuyoshi Nakamura, Naoki Kikuchi, Yasuhiro Shibata, Tetsushi Okimoto, Tomoaki Sakurai, Hideyuki Akimoto, Tetsuo Ono, Kota Daimon, Takashi Murayama, Shigeyuki Cancer Sci Original Articles We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (i) histologically proven bone sarcomas of the skull base or spine; (ii) no metastases; (iii) ≥20 years of age; and (iv) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed‐up for >6 months or had died within 6 months. Seventy‐two patients (75.0%) had chordoma, 20 patients (20.8%) had chondrosarcoma, and four patients (7.2%) had osteosarcoma. The most frequent tumor locations included the skull base in 68 patients (70.8%) and the sacral spine in 13 patients (13.5%). Patients received a median total dose of 70.0 Gy (relative biological effectiveness). The median follow‐up was 52.6 (range, 6.3–131.9) months. The 5‐year overall survival, progression‐free survival, and local control rates were 75.3%, 49.6%, and 71.1%, respectively. Performance status was a significant factor for overall survival and progression‐free survival, whilst sex was a significant factor for local control. Acute Grade 3 and late toxicities of ≥Grade 3 were observed in nine patients (9.4%) each (late Grade 4 toxicities [n = 3 patients; 3.1%]). No treatment‐related deaths occurred. Proton beam therapy is safe and effective for the treatment of bone sarcomas of the skull base and spine in Japan. However, larger prospective studies with a longer follow‐up are warranted. John Wiley and Sons Inc. 2017-04-24 2017-05 /pmc/articles/PMC5448607/ /pubmed/28182320 http://dx.doi.org/10.1111/cas.13192 Text en © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Demizu, Yusuke Mizumoto, Masashi Onoe, Tsuyoshi Nakamura, Naoki Kikuchi, Yasuhiro Shibata, Tetsushi Okimoto, Tomoaki Sakurai, Hideyuki Akimoto, Tetsuo Ono, Kota Daimon, Takashi Murayama, Shigeyuki Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan |
title | Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan |
title_full | Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan |
title_fullStr | Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan |
title_full_unstemmed | Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan |
title_short | Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan |
title_sort | proton beam therapy for bone sarcomas of the skull base and spine: a retrospective nationwide multicenter study in japan |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448607/ https://www.ncbi.nlm.nih.gov/pubmed/28182320 http://dx.doi.org/10.1111/cas.13192 |
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