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Three-Dimensional Cell Cultures in Drug Discovery and Development

The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease...

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Detalles Bibliográficos
Autores principales: Fang, Ye, Eglen, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448717/
https://www.ncbi.nlm.nih.gov/pubmed/28520521
http://dx.doi.org/10.1177/1087057117696795
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author Fang, Ye
Eglen, Richard M.
author_facet Fang, Ye
Eglen, Richard M.
author_sort Fang, Ye
collection PubMed
description The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles.
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spelling pubmed-54487172017-06-06 Three-Dimensional Cell Cultures in Drug Discovery and Development Fang, Ye Eglen, Richard M. SLAS Discov 3D Cell Culture, Drug Screening, and Optimization The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles. SAGE Publications 2017-05-18 2017-06 /pmc/articles/PMC5448717/ /pubmed/28520521 http://dx.doi.org/10.1177/1087057117696795 Text en © 2017 Society for Laboratory Automation and Screening http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle 3D Cell Culture, Drug Screening, and Optimization
Fang, Ye
Eglen, Richard M.
Three-Dimensional Cell Cultures in Drug Discovery and Development
title Three-Dimensional Cell Cultures in Drug Discovery and Development
title_full Three-Dimensional Cell Cultures in Drug Discovery and Development
title_fullStr Three-Dimensional Cell Cultures in Drug Discovery and Development
title_full_unstemmed Three-Dimensional Cell Cultures in Drug Discovery and Development
title_short Three-Dimensional Cell Cultures in Drug Discovery and Development
title_sort three-dimensional cell cultures in drug discovery and development
topic 3D Cell Culture, Drug Screening, and Optimization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448717/
https://www.ncbi.nlm.nih.gov/pubmed/28520521
http://dx.doi.org/10.1177/1087057117696795
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