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Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor

BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes involved in tumor progression in various cancers....

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Detalles Bibliográficos
Autores principales:	Fukushima, Suguru, Endo, Makoto, Matsumoto, Yoshihiro, Fukushi, Jun-ichi, Matsunobu, Tomoya, Kawaguchi, Ken-ichi, Setsu, Nokitaka, IIda, Keiichiro, Yokoyama, Nobuhiko, Nakagawa, Makoto, Yahiro, Kenichiro, Oda, Yoshinao, Iwamoto, Yukihide, Nakashima, Yasuharu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448771/ https://www.ncbi.nlm.nih.gov/pubmed/28558056 http://dx.doi.org/10.1371/journal.pone.0178064

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