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Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence
BACKGROUND: Defensins are important components of innate immunity to combat bacterial and viral infections, and can even elicit antitumor responses. Clusters of defensin (DEF) genes are located in a 2 Mb range of the human chromosome 8p23.1. This DEF locus, however, represents one of the regions in...
Autores principales: | Taudien, Stefan, Galgoczy, Petra, Huse, Klaus, Reichwald, Kathrin, Schilhabel, Markus, Szafranski, Karol, Shimizu, Atsushi, Asakawa, Shuichi, Frankish, Adam, Loncarevic, Ivan F, Shimizu, Nobuyoshi, Siddiqui, Roman, Platzer, Matthias |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544879/ https://www.ncbi.nlm.nih.gov/pubmed/15588320 http://dx.doi.org/10.1186/1471-2164-5-92 |
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