Cargando…

Low versus high dose of antimony for American cutaneous leishmaniasis: A randomized controlled blind non-inferiority trial in Rio de Janeiro, Brazil

BACKGROUND: Although high dose of antimony is the mainstay for treatment of American cutaneous leishmaniasis (ACL), ongoing major concerns remain over its toxicity. Whether or not low dose antimony regimens provide non-inferior effectiveness and lower toxicity has long been a question of dispute. ME...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saheki, Mauricio Naoto, Lyra, Marcelo Rosandiski, Bedoya-Pacheco, Sandro Javier, Antônio, Liliane de Fátima, Pimentel, Maria Inês Fernandes, Salgueiro, Mariza de Matos, Vasconcellos, Érica de Camargo Ferreira e, Passos, Sonia Regina Lambert, dos Santos, Ginelza Peres Lima, Ribeiro, Madelon Novato, Fagundes, Aline, Madeira, Maria de Fátima, Mouta-Confort, Eliame, Marzochi, Mauro Célio de Almeida, Valete-Rosalino, Cláudia Maria, Schubach, Armando de Oliveira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448803/ https://www.ncbi.nlm.nih.gov/pubmed/28558061 http://dx.doi.org/10.1371/journal.pone.0178592

Ejemplares similares

Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil
por: de Carvalho, Livia Martins Veloso, et al.
Publicado: (2017)

FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS
por: Ribeiro, Madelon Novato, et al.
Publicado: (2014)

An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
por: Oliveira-Ribeiro, Carla, et al.
Publicado: (2021)

PANCREATIC TOXICITY AS AN ADVERSE EFFECT INDUCED BY MEGLUMINE ANTIMONIATE THERAPY IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS
por: LYRA, Marcelo Rosandiski, et al.
Publicado: (2016)

Clinical and laboratory profiles of patients with early spontaneous healing in cutaneous localized leishmaniasis: a historical cohort study
por: Oliveira-Ribeiro, Carla, et al.
Publicado: (2017)

Low dose systemic or intralesional meglumine antimoniate treatment for American tegumentary leishmaniasis results in low lethality, low incidence of relapse, and low late mucosal involvement in a referral centre in Rio de Janeiro, Brazil (2001-2013)
por: Brahim, Lucia Regina, et al.
Publicado: (2017)

RESOLUTION OF CUTANEOUS LEISHMANIASIS AFTER ACUTE ECZEMA DUE TO INTRALESIONAL MEGLUMINE ANTIMONIATE
por: Vasconcellos, Erica de Camargo Ferreira e, et al.
Publicado: (2014)

FIRST REPORT OF CUTANEOUS LEISHMANIASIS CAUSED BYLeishmania (Leishmania) infantum chagasi IN AN URBAN AREA OF RIO DE JANEIRO, BRAZIL
por: LYRA, Marcelo Rosandiski, et al.
Publicado: (2015)

Description of the dermatoscopic features observed in sporotrichosis and American cutaneous leishmaniasis in a reference center in Rio de Janeiro, Brazil()
por: España, Alejandra Galeano, et al.
Publicado: (2023)

Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal?
por: Leite-Silva, Jéssica, et al.
Publicado: (2023)

FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE
por: Valete-Rosalino, Cláudia Maria, et al.
Publicado: (2014)

Oral Manifestations in the American Tegumentary Leishmaniasis
por: da Costa, Daniel Cesar Silva, et al.
Publicado: (2014)

Geospatial analysis of tegumentary leishmaniasis in Rio de Janeiro state, Brazil from 2000 to 2015: Species typing and flow of travelers and migrants with leishmaniasis
por: Miranda, Luciana de Freitas Campos, et al.
Publicado: (2019)

Genotypic profiles of Leishmania (Viannia) braziliensis strains from cutaneous leishmaniasis patients and their relationship with the response to meglumine antimoniate treatment: a pilot study
por: Gagini, Thalita, et al.
Publicado: (2017)

MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS
por: Antonio, Liliane de Fátima, et al.
Publicado: (2014)

Apoptosis and frequency of total and effector CD8(+) T lymphocytes from cutaneous leishmaniasis patients during antimonial therapy
por: Ferraz, Raquel, et al.
Publicado: (2015)

A novel case of human visceral leishmaniasis from the urban area of the city of Rio de Janeiro: autochthonous or imported from Spain ?
por: da Silva, Guilherme Almeida Rosa, et al.
Publicado: (2017)

Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
por: Antonio, Liliane de Fátima, et al.
Publicado: (2017)

Is There Any Difference between the In Situ and Systemic IL-10 and IFN-γ Production when Clinical Forms of Cutaneous Sporotrichosis Are Compared?
por: Morgado, Fernanda N., et al.
Publicado: (2016)

Alterations in Evoked Otoacoustic Emissions by the Use of Meglumine Antimoniate in American Tegumentary Leishmaniasis Patients
por: de Oliveira Bezerra, Débora Cristina, et al.
Publicado: (2017)

Clinical and epidemiological aspects of American cutaneous leishmaniasis with genital involvement()()
por: Lyra, Marcelo Rosandiski, et al.
Publicado: (2020)

T-cell receptor Vβ repertoire of CD8(+) T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil
por: Ferraz, Raquel, et al.
Publicado: (2015)

Two Women Presenting Worsening Cutaneous Ulcers during Pregnancy: Diagnosis, Immune Response, and Follow-up
por: Conceição-Silva, Fátima, et al.
Publicado: (2013)

Cat-transmitted Sporotrichosis, Rio de Janeiro, Brazil
por: Schubach, Armando, et al.
Publicado: (2005)

Comparison between Colorimetric In Situ Hybridization, Histopathology, and Immunohistochemistry for the Diagnosis of New World Cutaneous Leishmaniasis in Human Skin Samples
por: Ferreira, Luiz Cláudio, et al.
Publicado: (2022)

Serine proteases profiles of Leishmania (Viannia) braziliensis clinical isolates with distinct susceptibilities to antimony
por: Zabala-Peñafiel, Anabel, et al.
Publicado: (2021)

In Vitro Sensitivity of Paired Leishmania (Viannia) braziliensis Samples Isolated before Meglumine Antimoniate Treatment and after Treatment Failure or Reactivation of Cutaneous Leishmaniasis
por: Baptista, Cibele, et al.
Publicado: (2015)

First report of Leishmania RNA virus 1 in Leishmania (Viannia) braziliensis clinical isolates from Rio de Janeiro State - Brazil
por: Zabala-Peñafiel, Anabel, et al.
Publicado: (2022)

Are Neutrophil Extracellular Traps Playing a Role in the Parasite Control in Active American Tegumentary Leishmaniasis Lesions?
por: Morgado, Fernanda Nazaré, et al.
Publicado: (2015)

Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis
por: Reis, João Gustavo Corrêa, et al.
Publicado: (2016)

Disseminated intravascular coagulation in a dog naturally infected by Leishmania (Leishmania) chagasi from Rio de Janeiro – Brazil
por: Honse, Carla O, et al.
Publicado: (2013)

Comparison of parasite load by qPCR and histopathological changes of inner and outer edge of ulcerated cutaneous lesions of cutaneous leishmaniasis
por: Thomaz, Caio, et al.
Publicado: (2021)

Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil
por: Sampaio, Felipe Maurício Soeiro, et al.
Publicado: (2017)

Sporotrichosis: An Emerging Neglected Opportunistic Infection in HIV-Infected Patients in Rio de Janeiro, Brazil
por: Freitas, Dayvison Francis Saraiva, et al.
Publicado: (2014)

GEOGRAPHICAL EXPANSION OF CANINE VISCERAL LEISHMANIASIS IN RIO DE JANEIRO STATE, BRAZIL
por: da SILVA, Denise Amaro, et al.
Publicado: (2015)

Auditory screening in the elderly: comparison between self-report and audiometry
por: Valete-Rosalino, Cláudia Maria, et al.
Publicado: (2015)

Tuberculosis Control Program and patient satisfaction, Rio de Janeiro, Brazil
por: Portela, Margareth Crisóstomo, et al.
Publicado: (2014)

Voice Disorders in Mucosal Leishmaniasis
por: Ruas, Ana Cristina Nunes, et al.
Publicado: (2014)

CANINE VISCERAL LEISHMANIASIS CASE INVESTIGATION IN THE JACARE REGION OF NITEROI, RIO DE JANEIRO, BRAZIL
por: de OLIVEIRA, Amanda Codeço, et al.
Publicado: (2015)

CLINICAL-EPIDEMIOLOGICAL PROFILE OF 106 PEDIATRIC PACIENTS WITH UROLITHIASIS IN RIO DE JANEIRO, BRAZIL
por: Barata, Clarisse Barbosa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_khmq2vg5ijdlfivh9qnf2h70rq