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High-order epistasis shapes evolutionary trajectories
High-order epistasis—where the effect of a mutation is determined by interactions with two or more other mutations—makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important determinant of evolutionary trajectories, the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448810/ https://www.ncbi.nlm.nih.gov/pubmed/28505183 http://dx.doi.org/10.1371/journal.pcbi.1005541 |