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Mixture models reveal multiple positional bias types in RNA-Seq data and lead to accurate transcript concentration estimates
Accuracy of transcript quantification with RNA-Seq is negatively affected by positional fragment bias. This article introduces Mix(2) (rd. “mixquare”), a transcript quantification method which uses a mixture of probability distributions to model and thereby neutralize the effects of positional fragm...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448817/ https://www.ncbi.nlm.nih.gov/pubmed/28505151 http://dx.doi.org/10.1371/journal.pcbi.1005515 |