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Stem cells: the new “model organism”

Human tissue culture cells have long been a staple of molecular and cell biology research. However, although these cells are derived from humans, they have often lost considerable aspects of natural physiological function. Here we argue that combined advances in genome editing, stem cell production,...

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Detalles Bibliográficos
Autores principales: Drubin, David G., Hyman, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449140/
https://www.ncbi.nlm.nih.gov/pubmed/28559439
http://dx.doi.org/10.1091/mbc.E17-03-0183
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author Drubin, David G.
Hyman, Anthony A.
author_facet Drubin, David G.
Hyman, Anthony A.
author_sort Drubin, David G.
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description Human tissue culture cells have long been a staple of molecular and cell biology research. However, although these cells are derived from humans, they have often lost considerable aspects of natural physiological function. Here we argue that combined advances in genome editing, stem cell production, and organoid derivation from stem cells represent a revolution in cell biology. These advances have important ramifications for the study of basic cell biology mechanisms, as well as for the ways in which discoveries in mechanisms are translated into understanding of disease.
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spelling pubmed-54491402017-08-16 Stem cells: the new “model organism” Drubin, David G. Hyman, Anthony A. Mol Biol Cell Perspectives Human tissue culture cells have long been a staple of molecular and cell biology research. However, although these cells are derived from humans, they have often lost considerable aspects of natural physiological function. Here we argue that combined advances in genome editing, stem cell production, and organoid derivation from stem cells represent a revolution in cell biology. These advances have important ramifications for the study of basic cell biology mechanisms, as well as for the ways in which discoveries in mechanisms are translated into understanding of disease. The American Society for Cell Biology 2017-06-01 /pmc/articles/PMC5449140/ /pubmed/28559439 http://dx.doi.org/10.1091/mbc.E17-03-0183 Text en © 2017 Drubin and Hyman. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Perspectives
Drubin, David G.
Hyman, Anthony A.
Stem cells: the new “model organism”
title Stem cells: the new “model organism”
title_full Stem cells: the new “model organism”
title_fullStr Stem cells: the new “model organism”
title_full_unstemmed Stem cells: the new “model organism”
title_short Stem cells: the new “model organism”
title_sort stem cells: the new “model organism”
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449140/
https://www.ncbi.nlm.nih.gov/pubmed/28559439
http://dx.doi.org/10.1091/mbc.E17-03-0183
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