Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments. Whether tumors exploit unique biophysical properties to metastasize remains unclear. Data show that invading mammary tumor cells, when cultured in a stiffened three-dimensional extracel...

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Detalles Bibliográficos
Autores principales: Mekhdjian, Armen H., Kai, FuiBoon, Rubashkin, Matthew G., Prahl, Louis S., Przybyla, Laralynne M., McGregor, Alexandra L., Bell, Emily S., Barnes, J. Matthew, DuFort, Christopher C., Ou, Guanqing, Chang, Alice C., Cassereau, Luke, Tan, Steven J., Pickup, Michael W., Lakins, Jonathan N., Ye, Xin, Davidson, Michael W., Lammerding, Jan, Odde, David J., Dunn, Alexander R., Weaver, Valerie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449147/
https://www.ncbi.nlm.nih.gov/pubmed/28381423
http://dx.doi.org/10.1091/mbc.E16-09-0654

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