A selectivity filter at the intracellular end of the acid-sensing ion channel pore

Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification i...

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Detalles Bibliográficos
Autores principales: Lynagh, Timothy, Flood, Emelie, Boiteux, Céline, Wulf, Matthias, Komnatnyy, Vitaly V, Colding, Janne M, Allen, Toby W, Pless, Stephan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449180/
https://www.ncbi.nlm.nih.gov/pubmed/28498103
http://dx.doi.org/10.7554/eLife.24630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449180/
https://www.ncbi.nlm.nih.gov/pubmed/28498103
http://dx.doi.org/10.7554/eLife.24630

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