Cargando…

Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for the determination of VNT in two various matrices including rat liver microsomes (RLMs) and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amer, Sawsan M., Kadi, Adnan A., Darwish, Hany W., Attwa, Mohamed W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449356/ https://www.ncbi.nlm.nih.gov/pubmed/29086823 http://dx.doi.org/10.1186/s13065-017-0274-4

Ejemplares similares

Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry
por: Kadi, Adnan A., et al.
Publicado: (2018)

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry
por: Attwa, Mohamed W, et al.
Publicado: (2020)

Reactive intermediates in naquotinib metabolism identified by liquid chromatography-tandem mass spectrometry: phase I metabolic profiling
por: Attwa, Mohamed W., et al.
Publicado: (2019)

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Validated liquid chromatography tandem mass spectrometry for simultaneous quantification of foretinib and lapatinib, and application to metabolic stability investigation
por: Alanazi, Mohammed M., et al.
Publicado: (2019)

Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability
por: Kadi, Adnan A., et al.
Publicado: (2016)

Liquid chromatography–tandem mass spectrometry metabolic profiling of nazartinib reveals the formation of unexpected reactive metabolites
por: Abdelhameed, Ali S., et al.
Publicado: (2019)

LC–MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate
por: Amer, Sawsan M., et al.
Publicado: (2017)

A simple liquid chromatography-tandem mass spectrometry method to accurately determine the novel third-generation EGFR-TKI naquotinib with its applicability to metabolic stability assessment
por: Alrabiah, Haitham, et al.
Publicado: (2019)

A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation
por: Alanazi, Mohammed M., et al.
Publicado: (2022)

Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation
por: Attwa, Mohamed W., et al.
Publicado: (2023)

A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2022)

Hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method for quantification of five phospholipid classes in various matrices
por: Mazzella, Nicolas, et al.
Publicado: (2023)

A Validated LC–MS/MS Assay for the Simultaneous Quantification of the FDA-Approved Anticancer Mixture (Encorafenib and Binimetinib): Metabolic Stability Estimation
por: Attwa, Mohamed W., et al.
Publicado: (2021)

Analysis of β-agonists in Different Biological Matrices By Liquid Chromatography–tandem Mass Spectrometry
por: Śniegocki, Tomasz, et al.
Publicado: (2021)

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation
por: Attwa, Mohamed W, et al.
Publicado: (2021)

Profiling of in vivo, in vitro and reactive zorifertinib metabolites using liquid chromatography ion trap mass spectrometry
por: Al-Shakliah, Nasser S., et al.
Publicado: (2022)

Identification and Quantification of Dimethylamylamine in Geranium by Liquid Chromatography Tandem Mass Spectrometry
por: Li, J.S., et al.
Publicado: (2012)

Quantification of cystine in human renal proximal tubule cells using liquid chromatography–tandem mass spectrometry
por: Jamalpoor, Amer, et al.
Publicado: (2018)

Study of in-vitro metabolism of selected antibiotic drugs in human liver microsomes by liquid chromatography coupled with tandem mass spectrometry
por: Szultka-Mlynska, Malgorzata, et al.
Publicado: (2016)

Quantification of Human Plasma-Busulfan Concentration by Liquid Chromatography-Tandem Mass Spectrometry
por: Moon, Soo Young, et al.
Publicado: (2014)

Identification and Quantification of Glucosinolates in Kimchi by Liquid Chromatography-Electrospray Tandem Mass Spectrometry
por: Kim, Ho Jin, et al.
Publicado: (2017)

Liquid Chromatography Tandem Mass Spectrometry Quantification of (13)C-Labeling in Sugars
por: Cocuron, Jean-Christophe, et al.
Publicado: (2020)

Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry
por: Lindegardh, N., et al.
Publicado: (2009)

Simultaneous Quantification of Multiple Urinary Naphthalene Metabolites by Liquid Chromatography Tandem Mass Spectrometry
por: Ayala, Daniel C., et al.
Publicado: (2015)

Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography–tandem mass spectrometry
por: Shah, Jaivik V., et al.
Publicado: (2017)

Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry
por: El Amrani, Mohsin, et al.
Publicado: (2018)

Simultaneous Quantification of Trace and Micro Phenolic Compounds by Liquid Chromatography Tandem-Mass Spectrometry
por: Wang, Dandan, et al.
Publicado: (2021)

Simple and fast quantification of cannabinoids in animal feeds by liquid chromatography–tandem mass spectrometry
por: Xu, Xin, et al.
Publicado: (2023)

LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay
por: Attwa, Mohamed W, et al.
Publicado: (2020)

Quantitative Bottom-Up Glycomic Analysis of Polysaccharides in Food Matrices Using Liquid Chromatography–Tandem Mass Spectrometry
por: Bacalzo, Nikita P., et al.
Publicado: (2022)

LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways
por: Kadi, Adnan A., et al.
Publicado: (2018)

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach
por: Abdelhameed, Ali S, et al.
Publicado: (2020)

Quantification of isocyanates and amines in polyurethane foams and coated products by liquid chromatography–tandem mass spectrometry
por: Mutsuga, Motoh, et al.
Publicado: (2014)

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
por: Wong, Andrea Li-Ann, et al.
Publicado: (2018)

High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II
por: Wang, Junhua, et al.
Publicado: (2020)

Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry
por: Laforest, Sofia, et al.
Publicado: (2019)

Quantification of Colistin in Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study
por: Matar, Kamal M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cavdcfjknosn6p3vs6sp8tbio1