Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain t...

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Detalles Bibliográficos
Autores principales: LeBlanc, Brian W., Cross, Brent, Smith, Kelsey A., Roach, Catherine, Xia, Jimmy, Chao, Yu-Chieh, Levitt, Joshua, Koyama, Suguru, Moore, Christopher I., Saab, Carl Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449396/
https://www.ncbi.nlm.nih.gov/pubmed/28559582
http://dx.doi.org/10.1038/s41598-017-02753-6
Descripción
Sumario:We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.

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