Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain t...

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Autores principales: LeBlanc, Brian W., Cross, Brent, Smith, Kelsey A., Roach, Catherine, Xia, Jimmy, Chao, Yu-Chieh, Levitt, Joshua, Koyama, Suguru, Moore, Christopher I., Saab, Carl Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449396/
https://www.ncbi.nlm.nih.gov/pubmed/28559582
http://dx.doi.org/10.1038/s41598-017-02753-6
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author LeBlanc, Brian W.
Cross, Brent
Smith, Kelsey A.
Roach, Catherine
Xia, Jimmy
Chao, Yu-Chieh
Levitt, Joshua
Koyama, Suguru
Moore, Christopher I.
Saab, Carl Y.
author_facet LeBlanc, Brian W.
Cross, Brent
Smith, Kelsey A.
Roach, Catherine
Xia, Jimmy
Chao, Yu-Chieh
Levitt, Joshua
Koyama, Suguru
Moore, Christopher I.
Saab, Carl Y.
author_sort LeBlanc, Brian W.
collection PubMed
description We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.
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spelling pubmed-54493962017-06-01 Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior LeBlanc, Brian W. Cross, Brent Smith, Kelsey A. Roach, Catherine Xia, Jimmy Chao, Yu-Chieh Levitt, Joshua Koyama, Suguru Moore, Christopher I. Saab, Carl Y. Sci Rep Article We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience. Nature Publishing Group UK 2017-05-30 /pmc/articles/PMC5449396/ /pubmed/28559582 http://dx.doi.org/10.1038/s41598-017-02753-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
LeBlanc, Brian W.
Cross, Brent
Smith, Kelsey A.
Roach, Catherine
Xia, Jimmy
Chao, Yu-Chieh
Levitt, Joshua
Koyama, Suguru
Moore, Christopher I.
Saab, Carl Y.
Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_full Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_fullStr Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_full_unstemmed Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_short Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_sort thalamic bursts down-regulate cortical theta and nociceptive behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449396/
https://www.ncbi.nlm.nih.gov/pubmed/28559582
http://dx.doi.org/10.1038/s41598-017-02753-6
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