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CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training

Although circulating fatty acids are utilized as energy substrates, they also function as ligands to the peroxisome‐proliferator activated receptors (PPARs), a family of fatty acid sensing transcription factors. Exercise training leads to various adaptations in the muscle such as elevation of glycog...

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Autores principales: Manio, Mark Christian C., Matsumura, Shigenobu, Masuda, Daisaku, Inoue, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449563/
https://www.ncbi.nlm.nih.gov/pubmed/28526781
http://dx.doi.org/10.14814/phy2.13282
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author Manio, Mark Christian C.
Matsumura, Shigenobu
Masuda, Daisaku
Inoue, Kazuo
author_facet Manio, Mark Christian C.
Matsumura, Shigenobu
Masuda, Daisaku
Inoue, Kazuo
author_sort Manio, Mark Christian C.
collection PubMed
description Although circulating fatty acids are utilized as energy substrates, they also function as ligands to the peroxisome‐proliferator activated receptors (PPARs), a family of fatty acid sensing transcription factors. Exercise training leads to various adaptations in the muscle such as elevation of glycogen content, mitochondrial number as well as upregulation of fatty acid uptake and utilization through downstream transcriptional adaptations. In line with this, CD36 has been shown to be critical in controlling fatty acid uptake and consequently, fatty acid oxidation. We show that exercise training could not ameliorate impaired endurance performance in CD36 KO mice despite intact adaptations in muscle glycogen storage and mitochondrial function. Changes in whole‐body metabolism at rest and during exercise were also suppressed in these animals. Furthermore, there was inefficient upregulation of PPAR and PPAR‐related exercise‐responsive genes with chronic training in CD36 KO mice despite normal upregulation of Pgc1a and mitochondrial genes. Our findings supplement previous observations and emphasize the importance of CD36 in endurance performance, energy production and efficient downstream transcriptional regulation by PPARs.
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spelling pubmed-54495632017-06-01 CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training Manio, Mark Christian C. Matsumura, Shigenobu Masuda, Daisaku Inoue, Kazuo Physiol Rep Original Research Although circulating fatty acids are utilized as energy substrates, they also function as ligands to the peroxisome‐proliferator activated receptors (PPARs), a family of fatty acid sensing transcription factors. Exercise training leads to various adaptations in the muscle such as elevation of glycogen content, mitochondrial number as well as upregulation of fatty acid uptake and utilization through downstream transcriptional adaptations. In line with this, CD36 has been shown to be critical in controlling fatty acid uptake and consequently, fatty acid oxidation. We show that exercise training could not ameliorate impaired endurance performance in CD36 KO mice despite intact adaptations in muscle glycogen storage and mitochondrial function. Changes in whole‐body metabolism at rest and during exercise were also suppressed in these animals. Furthermore, there was inefficient upregulation of PPAR and PPAR‐related exercise‐responsive genes with chronic training in CD36 KO mice despite normal upregulation of Pgc1a and mitochondrial genes. Our findings supplement previous observations and emphasize the importance of CD36 in endurance performance, energy production and efficient downstream transcriptional regulation by PPARs. John Wiley and Sons Inc. 2017-05-19 /pmc/articles/PMC5449563/ /pubmed/28526781 http://dx.doi.org/10.14814/phy2.13282 Text en © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Manio, Mark Christian C.
Matsumura, Shigenobu
Masuda, Daisaku
Inoue, Kazuo
CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training
title CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training
title_full CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training
title_fullStr CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training
title_full_unstemmed CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training
title_short CD36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient PPAR‐related transcriptional responses in the muscle with exercise training
title_sort cd36 is essential for endurance improvement, changes in whole‐body metabolism, and efficient ppar‐related transcriptional responses in the muscle with exercise training
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449563/
https://www.ncbi.nlm.nih.gov/pubmed/28526781
http://dx.doi.org/10.14814/phy2.13282
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