Predicting transcription factor binding motifs from DNA-binding domains, chromatin accessibility and gene expression data

Transcription factors (TFs) play crucial roles in regulating gene expression through interactions with specific DNA sequences. Recently, the sequence motif of almost 400 human TFs have been identified using high-throughput SELEX sequencing. However, there remain a large number of TFs (∼800) with no...

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Detalles Bibliográficos
Autores principales: Zamanighomi, Mahdi, Lin, Zhixiang, Wang, Yong, Jiang, Rui, Wong, Wing Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449588/
https://www.ncbi.nlm.nih.gov/pubmed/28472398
http://dx.doi.org/10.1093/nar/gkx358

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