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Random pseuoduridylation in vivo reveals critical region of Escherichia coli 23S rRNA for ribosome assembly

Pseudouridine is the most common modified nucleoside in RNA, which is found in stable RNA species and in eukaryotic mRNAs. Functional analysis of pseudouridine is complicated by marginal effect of its absence. We demonstrate that excessive pseudouridines in rRNA inhibit ribosome assembly. Ten-fold i...

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Detalles Bibliográficos
Autores principales:	Leppik, Margus, Liiv, Aivar, Remme, Jaanus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449589/ https://www.ncbi.nlm.nih.gov/pubmed/28334881 http://dx.doi.org/10.1093/nar/gkx160

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