TDP-43 suppresses tau expression via promoting its mRNA instability

In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we...

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Detalles Bibliográficos
Autores principales: Gu, Jianlan, Wu, Feng, Xu, Wen, Shi, Jianhua, Hu, Wen, Jin, Nana, Qian, Wei, Wang, Xinglong, Iqbal, Khalid, Gong, Cheng-Xin, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449590/
https://www.ncbi.nlm.nih.gov/pubmed/28335005
http://dx.doi.org/10.1093/nar/gkx175

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