Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA

G-quadruplex or G4 DNA is a non-B secondary DNA structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular functions such as replication and transcription. When sequences that can adopt Non-B structures including G4 DNA are located within actively transcribed gene...

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Detalles Bibliográficos
Autores principales: Lopez, Christopher R., Singh, Shivani, Hambarde, Shashank, Griffin, Wezley C., Gao, Jun, Chib, Shubeena, Yu, Yang, Ira, Grzegorz, Raney, Kevin D., Kim, Nayun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449603/
https://www.ncbi.nlm.nih.gov/pubmed/28369605
http://dx.doi.org/10.1093/nar/gkx201

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