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New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

Comparative modeling of the DNA-binding domain of human HSF1 facilitated the prediction of possible binding pockets for small molecules and definition of corresponding pharmacophores. In silico screening of a large library of lead-like compounds identified a set of compounds that satisfied the pharm...

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Detalles Bibliográficos
Autores principales:	Vilaboa, Nuria, Boré, Alba, Martin-Saavedra, Francisco, Bayford, Melanie, Winfield, Natalie, Firth-Clark, Stuart, Kirton, Stewart B., Voellmy, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449623/ https://www.ncbi.nlm.nih.gov/pubmed/28369544 http://dx.doi.org/10.1093/nar/gkx194

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