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Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China

BACKGROUND: Little information on the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. METHODS: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination...

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Autores principales: Zhang, Tiejun, Liu, Zhenqiu, Wang, Jun, Minhas, Veenu, Wood, Charles, Clifford, Gary M., He, Na, Franceschi, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450136/
https://www.ncbi.nlm.nih.gov/pubmed/28572838
http://dx.doi.org/10.1186/s13027-017-0142-9
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author Zhang, Tiejun
Liu, Zhenqiu
Wang, Jun
Minhas, Veenu
Wood, Charles
Clifford, Gary M.
He, Na
Franceschi, Silvia
author_facet Zhang, Tiejun
Liu, Zhenqiu
Wang, Jun
Minhas, Veenu
Wood, Charles
Clifford, Gary M.
He, Na
Franceschi, Silvia
author_sort Zhang, Tiejun
collection PubMed
description BACKGROUND: Little information on the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. METHODS: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China. KSHV-specific antibodies against latent and lytic antigens were assessed using Sf9 and BC3 monoclonal immunofluorescence assay. Age-adjusted prevalence ratios (PR) and 95% confidence interval (95% CI) for KSHV-positivity were estimated using Poisson regression. RESULTS: In total, 4184 HIV-negative participants were included. KSHV prevalence ranged from 9.8% (95% CI: 7.9%-11.7%) in male migrants to 32.3% (95% CI: 24.1%-34.1%) in MSM. IVDU show intermediate level (17.5%, 95%CI: 14.1%-21.4%). KSHV was associated with syphilis (PR = 2.03, 95% CI: 1.38-2.98) in MSM but not in other groups. An association with human herpes virus 2 was also found among MSM (PR = 1. 83, 95%: 1.22-2.75) but not in migrant workers or FSW. CONCLUSIONS: KSHV prevalence in HIV-negative heterosexuals, FSW, and STI male patients from China is approximately 10%, but 2- and 3-fold higher in IVDU and MSM, respectively. Associations of KSHV with STIs among MSM only suggest that sexual transmission of the virus is important in MSM but not in heterosexuals.
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spelling pubmed-54501362017-06-01 Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China Zhang, Tiejun Liu, Zhenqiu Wang, Jun Minhas, Veenu Wood, Charles Clifford, Gary M. He, Na Franceschi, Silvia Infect Agent Cancer Short Report BACKGROUND: Little information on the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. METHODS: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China. KSHV-specific antibodies against latent and lytic antigens were assessed using Sf9 and BC3 monoclonal immunofluorescence assay. Age-adjusted prevalence ratios (PR) and 95% confidence interval (95% CI) for KSHV-positivity were estimated using Poisson regression. RESULTS: In total, 4184 HIV-negative participants were included. KSHV prevalence ranged from 9.8% (95% CI: 7.9%-11.7%) in male migrants to 32.3% (95% CI: 24.1%-34.1%) in MSM. IVDU show intermediate level (17.5%, 95%CI: 14.1%-21.4%). KSHV was associated with syphilis (PR = 2.03, 95% CI: 1.38-2.98) in MSM but not in other groups. An association with human herpes virus 2 was also found among MSM (PR = 1. 83, 95%: 1.22-2.75) but not in migrant workers or FSW. CONCLUSIONS: KSHV prevalence in HIV-negative heterosexuals, FSW, and STI male patients from China is approximately 10%, but 2- and 3-fold higher in IVDU and MSM, respectively. Associations of KSHV with STIs among MSM only suggest that sexual transmission of the virus is important in MSM but not in heterosexuals. BioMed Central 2017-05-30 /pmc/articles/PMC5450136/ /pubmed/28572838 http://dx.doi.org/10.1186/s13027-017-0142-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Zhang, Tiejun
Liu, Zhenqiu
Wang, Jun
Minhas, Veenu
Wood, Charles
Clifford, Gary M.
He, Na
Franceschi, Silvia
Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China
title Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China
title_full Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China
title_fullStr Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China
title_full_unstemmed Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China
title_short Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China
title_sort seroprevalence of antibodies against kaposi's sarcoma-associated herpesvirus among hiv-negative people in china
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450136/
https://www.ncbi.nlm.nih.gov/pubmed/28572838
http://dx.doi.org/10.1186/s13027-017-0142-9
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