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Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain
OBJECTIVE: The present study was aimed to investigate the neuroprotective effects of Decalepis hamiltonii (Dh) aqueous root extract and its compounds against age-related oxidative stress (OS) in the discrete regions of the rat brain. MATERIALS AND METHODS: Male Wistar albino rats of 4- and 22-month-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450474/ https://www.ncbi.nlm.nih.gov/pubmed/28584487 http://dx.doi.org/10.4103/0975-7406.206219 |
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author | Sowbhagya, Ramachandregowda Anupama, Siddhaghatta Kariyappa Bhagyalakshmi, Dundaiah Anand, Santosh Ravikiran, Tekupalli |
author_facet | Sowbhagya, Ramachandregowda Anupama, Siddhaghatta Kariyappa Bhagyalakshmi, Dundaiah Anand, Santosh Ravikiran, Tekupalli |
author_sort | Sowbhagya, Ramachandregowda |
collection | PubMed |
description | OBJECTIVE: The present study was aimed to investigate the neuroprotective effects of Decalepis hamiltonii (Dh) aqueous root extract and its compounds against age-related oxidative stress (OS) in the discrete regions of the rat brain. MATERIALS AND METHODS: Male Wistar albino rats of 4- and 22-month-old were divided into control and six supplemented groups. The supplemented groups were orally administered with ellagic acid (EA), 4-hydroxyisophthalic acid (4-HIA), and Dh extract for 30 days. RESULTS: Age-related decrease in antioxidant enzyme activities was noticed. The hippocampus was found to be more vulnerable to OS as seen by the elevation in the OS markers. Supplementation of the Dh extract, EA, and 4-HIA was found to be effective in up-regulating the antioxidant status. However, the extent of up-regulation was more evident in Dh supplemented animals. CONCLUSION: Our results suggest that Dh extract and its compounds exhibit neuroprotective effects against age-related OS and can be used as a dietary therapeutic intervention for the treatment of neurological disorders. |
format | Online Article Text |
id | pubmed-5450474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54504742017-06-05 Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain Sowbhagya, Ramachandregowda Anupama, Siddhaghatta Kariyappa Bhagyalakshmi, Dundaiah Anand, Santosh Ravikiran, Tekupalli J Pharm Bioallied Sci Original Article OBJECTIVE: The present study was aimed to investigate the neuroprotective effects of Decalepis hamiltonii (Dh) aqueous root extract and its compounds against age-related oxidative stress (OS) in the discrete regions of the rat brain. MATERIALS AND METHODS: Male Wistar albino rats of 4- and 22-month-old were divided into control and six supplemented groups. The supplemented groups were orally administered with ellagic acid (EA), 4-hydroxyisophthalic acid (4-HIA), and Dh extract for 30 days. RESULTS: Age-related decrease in antioxidant enzyme activities was noticed. The hippocampus was found to be more vulnerable to OS as seen by the elevation in the OS markers. Supplementation of the Dh extract, EA, and 4-HIA was found to be effective in up-regulating the antioxidant status. However, the extent of up-regulation was more evident in Dh supplemented animals. CONCLUSION: Our results suggest that Dh extract and its compounds exhibit neuroprotective effects against age-related OS and can be used as a dietary therapeutic intervention for the treatment of neurological disorders. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5450474/ /pubmed/28584487 http://dx.doi.org/10.4103/0975-7406.206219 Text en Copyright: © 2017 Journal of Pharmacy And Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sowbhagya, Ramachandregowda Anupama, Siddhaghatta Kariyappa Bhagyalakshmi, Dundaiah Anand, Santosh Ravikiran, Tekupalli Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain |
title | Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain |
title_full | Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain |
title_fullStr | Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain |
title_full_unstemmed | Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain |
title_short | Modulatory Effects of Decalepis hamiltonii Extract and Its Compounds on the Antioxidant Status of the Aging Rat Brain |
title_sort | modulatory effects of decalepis hamiltonii extract and its compounds on the antioxidant status of the aging rat brain |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450474/ https://www.ncbi.nlm.nih.gov/pubmed/28584487 http://dx.doi.org/10.4103/0975-7406.206219 |
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