Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79

Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4–11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these com...

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Detalles Bibliográficos
Autores principales: Hu, Xue-Yi, Meng, Ling-Hong, Li, Xin, Yang, Sui-Qun, Li, Xiao-Ming, Wang, Bin-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450543/
https://www.ncbi.nlm.nih.gov/pubmed/28498358
http://dx.doi.org/10.3390/md15050137
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author Hu, Xue-Yi
Meng, Ling-Hong
Li, Xin
Yang, Sui-Qun
Li, Xiao-Ming
Wang, Bin-Gui
author_facet Hu, Xue-Yi
Meng, Ling-Hong
Li, Xin
Yang, Sui-Qun
Li, Xiao-Ming
Wang, Bin-Gui
author_sort Hu, Xue-Yi
collection PubMed
description Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4–11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes.
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spelling pubmed-54505432017-06-05 Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79 Hu, Xue-Yi Meng, Ling-Hong Li, Xin Yang, Sui-Qun Li, Xiao-Ming Wang, Bin-Gui Mar Drugs Article Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4–11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes. MDPI 2017-05-12 /pmc/articles/PMC5450543/ /pubmed/28498358 http://dx.doi.org/10.3390/md15050137 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Xue-Yi
Meng, Ling-Hong
Li, Xin
Yang, Sui-Qun
Li, Xiao-Ming
Wang, Bin-Gui
Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
title Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
title_full Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
title_fullStr Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
title_full_unstemmed Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
title_short Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
title_sort three new indole diterpenoids from the sea-anemone-derived fungus penicillium sp. as-79
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450543/
https://www.ncbi.nlm.nih.gov/pubmed/28498358
http://dx.doi.org/10.3390/md15050137
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