Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa

The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedit...

Descripción completa

Detalles Bibliográficos
Autores principales: Braña, Alfredo F., Sarmiento-Vizcaíno, Aida, Osset, Miguel, Pérez-Victoria, Ignacio, Martín, Jesús, de Pedro, Nuria, de la Cruz, Mercedes, Díaz, Caridad, Vicente, Francisca, Reyes, Fernando, García, Luis A., Blanco, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450550/
https://www.ncbi.nlm.nih.gov/pubmed/28534807
http://dx.doi.org/10.3390/md15050144
Descripción
Sumario:The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.

Ejemplares similares