Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa

The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedit...

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Autores principales: Braña, Alfredo F., Sarmiento-Vizcaíno, Aida, Osset, Miguel, Pérez-Victoria, Ignacio, Martín, Jesús, de Pedro, Nuria, de la Cruz, Mercedes, Díaz, Caridad, Vicente, Francisca, Reyes, Fernando, García, Luis A., Blanco, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450550/
https://www.ncbi.nlm.nih.gov/pubmed/28534807
http://dx.doi.org/10.3390/md15050144
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author Braña, Alfredo F.
Sarmiento-Vizcaíno, Aida
Osset, Miguel
Pérez-Victoria, Ignacio
Martín, Jesús
de Pedro, Nuria
de la Cruz, Mercedes
Díaz, Caridad
Vicente, Francisca
Reyes, Fernando
García, Luis A.
Blanco, Gloria
author_facet Braña, Alfredo F.
Sarmiento-Vizcaíno, Aida
Osset, Miguel
Pérez-Victoria, Ignacio
Martín, Jesús
de Pedro, Nuria
de la Cruz, Mercedes
Díaz, Caridad
Vicente, Francisca
Reyes, Fernando
García, Luis A.
Blanco, Gloria
author_sort Braña, Alfredo F.
collection PubMed
description The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.
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spelling pubmed-54505502017-06-05 Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa Braña, Alfredo F. Sarmiento-Vizcaíno, Aida Osset, Miguel Pérez-Victoria, Ignacio Martín, Jesús de Pedro, Nuria de la Cruz, Mercedes Díaz, Caridad Vicente, Francisca Reyes, Fernando García, Luis A. Blanco, Gloria Mar Drugs Article The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus. MDPI 2017-05-19 /pmc/articles/PMC5450550/ /pubmed/28534807 http://dx.doi.org/10.3390/md15050144 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Braña, Alfredo F.
Sarmiento-Vizcaíno, Aida
Osset, Miguel
Pérez-Victoria, Ignacio
Martín, Jesús
de Pedro, Nuria
de la Cruz, Mercedes
Díaz, Caridad
Vicente, Francisca
Reyes, Fernando
García, Luis A.
Blanco, Gloria
Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
title Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
title_full Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
title_fullStr Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
title_full_unstemmed Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
title_short Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
title_sort lobophorin k, a new natural product with cytotoxic activity produced by streptomyces sp. m-207 associated with the deep-sea coral lophelia pertusa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450550/
https://www.ncbi.nlm.nih.gov/pubmed/28534807
http://dx.doi.org/10.3390/md15050144
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