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Non-bonding 1,5-S···O interactions govern chemo- and enantioselectivity in isothiourea-catalyzed annulations of benzazoles

Isothiourea-catalyzed annulations between 2-acyl benzazoles and α,β-unsaturated acyl ammonium intermediates are selectively tuned to form either lactam or lactone heterocycles in good yields (up to 95%) and high ee (up to 99%) using benzothiazole or benzoxazole derivatives, respectively. Computation...

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Detalles Bibliográficos
Autores principales:	Robinson, Emily R. T., Walden, Daniel M., Fallan, Charlene, Greenhalgh, Mark D., Cheong, Paul Ha-Yeon, Smith, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450589/ https://www.ncbi.nlm.nih.gov/pubmed/28567263 http://dx.doi.org/10.1039/c6sc00940a

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