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Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References

The use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evo...

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Autores principales: She, Shenglin, Li, Haijing, Ning, Yuping, Ren, Jianjuan, Wu, Zhangying, Huang, Rongcheng, Zhao, Jingping, Wang, Qian, Zheng, Yingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450627/
https://www.ncbi.nlm.nih.gov/pubmed/28620278
http://dx.doi.org/10.3389/fnins.2017.00314
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author She, Shenglin
Li, Haijing
Ning, Yuping
Ren, Jianjuan
Wu, Zhangying
Huang, Rongcheng
Zhao, Jingping
Wang, Qian
Zheng, Yingjun
author_facet She, Shenglin
Li, Haijing
Ning, Yuping
Ren, Jianjuan
Wu, Zhangying
Huang, Rongcheng
Zhao, Jingping
Wang, Qian
Zheng, Yingjun
author_sort She, Shenglin
collection PubMed
description The use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evoked early components of ERPs and mismatch negativities (MMNs). In most studies, the choice of reference has been the average reference (AVE), but whether this is the most suitable choice is still unknown. The aim of this study was to systematically compare the AVE and reference electrode standardization technique (REST) methods for assessing expressional face-evoked early visual ERPs and visual MMNs (vMMNs) in patients with schizophrenia and healthy controls. The results showed that both the AVE and REST methods could: (1) obtain primary visual-evoked ERPs in the two groups, (2) reveal the neutral and emotional expression discrimination deficit of the P1 component in the patients, which was normal in the healthy controls, (3) reflect reductions of happy vMMNs in the patients compared to the healthy controls, and (4) show right-dominant sad vMMNs only in the patients. On the other hand, compared to the energy distributions of the AVE-obtained potentials, those of REST-obtained early visual ERPs and vMMNs were more concentrated around the temporo-occipital areas. Furthermore, only the REST-obtained vMMNs revealed a significant difference between happy and sad mismatch stimuli in patients with schizophrenia. These results demonstrate that REST technology might provide new insights into neurophysiological factors associated with neuropsychiatric disorders.
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spelling pubmed-54506272017-06-15 Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References She, Shenglin Li, Haijing Ning, Yuping Ren, Jianjuan Wu, Zhangying Huang, Rongcheng Zhao, Jingping Wang, Qian Zheng, Yingjun Front Neurosci Neuroscience The use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evoked early components of ERPs and mismatch negativities (MMNs). In most studies, the choice of reference has been the average reference (AVE), but whether this is the most suitable choice is still unknown. The aim of this study was to systematically compare the AVE and reference electrode standardization technique (REST) methods for assessing expressional face-evoked early visual ERPs and visual MMNs (vMMNs) in patients with schizophrenia and healthy controls. The results showed that both the AVE and REST methods could: (1) obtain primary visual-evoked ERPs in the two groups, (2) reveal the neutral and emotional expression discrimination deficit of the P1 component in the patients, which was normal in the healthy controls, (3) reflect reductions of happy vMMNs in the patients compared to the healthy controls, and (4) show right-dominant sad vMMNs only in the patients. On the other hand, compared to the energy distributions of the AVE-obtained potentials, those of REST-obtained early visual ERPs and vMMNs were more concentrated around the temporo-occipital areas. Furthermore, only the REST-obtained vMMNs revealed a significant difference between happy and sad mismatch stimuli in patients with schizophrenia. These results demonstrate that REST technology might provide new insights into neurophysiological factors associated with neuropsychiatric disorders. Frontiers Media S.A. 2017-05-31 /pmc/articles/PMC5450627/ /pubmed/28620278 http://dx.doi.org/10.3389/fnins.2017.00314 Text en Copyright © 2017 She, Li, Ning, Ren, Wu, Huang, Zhao, Wang and Zheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
She, Shenglin
Li, Haijing
Ning, Yuping
Ren, Jianjuan
Wu, Zhangying
Huang, Rongcheng
Zhao, Jingping
Wang, Qian
Zheng, Yingjun
Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
title Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
title_full Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
title_fullStr Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
title_full_unstemmed Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
title_short Revealing the Dysfunction of Schematic Facial-Expression Processing in Schizophrenia: A Comparative Study of Different References
title_sort revealing the dysfunction of schematic facial-expression processing in schizophrenia: a comparative study of different references
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450627/
https://www.ncbi.nlm.nih.gov/pubmed/28620278
http://dx.doi.org/10.3389/fnins.2017.00314
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