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Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451000/ https://www.ncbi.nlm.nih.gov/pubmed/28562685 http://dx.doi.org/10.1371/journal.pone.0177722 |
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author | Seong, Jeong Min Yoon, Yo Sang Lee, Kyu Su Bae, Nan Young Gi, Mi Young Yoon, Hyun |
author_facet | Seong, Jeong Min Yoon, Yo Sang Lee, Kyu Su Bae, Nan Young Gi, Mi Young Yoon, Hyun |
author_sort | Seong, Jeong Min |
collection | PubMed |
description | BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL). RESULTS: The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456). CONCLUSION: Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women. |
format | Online Article Text |
id | pubmed-5451000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54510002017-06-12 Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults Seong, Jeong Min Yoon, Yo Sang Lee, Kyu Su Bae, Nan Young Gi, Mi Young Yoon, Hyun PLoS One Research Article BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL). RESULTS: The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456). CONCLUSION: Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women. Public Library of Science 2017-05-31 /pmc/articles/PMC5451000/ /pubmed/28562685 http://dx.doi.org/10.1371/journal.pone.0177722 Text en © 2017 Seong et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Seong, Jeong Min Yoon, Yo Sang Lee, Kyu Su Bae, Nan Young Gi, Mi Young Yoon, Hyun Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults |
title | Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults |
title_full | Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults |
title_fullStr | Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults |
title_full_unstemmed | Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults |
title_short | Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults |
title_sort | gender difference in relationship between serum ferritin and 25-hydroxyvitamin d in korean adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451000/ https://www.ncbi.nlm.nih.gov/pubmed/28562685 http://dx.doi.org/10.1371/journal.pone.0177722 |
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