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Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults

BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the...

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Autores principales: Seong, Jeong Min, Yoon, Yo Sang, Lee, Kyu Su, Bae, Nan Young, Gi, Mi Young, Yoon, Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451000/
https://www.ncbi.nlm.nih.gov/pubmed/28562685
http://dx.doi.org/10.1371/journal.pone.0177722
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author Seong, Jeong Min
Yoon, Yo Sang
Lee, Kyu Su
Bae, Nan Young
Gi, Mi Young
Yoon, Hyun
author_facet Seong, Jeong Min
Yoon, Yo Sang
Lee, Kyu Su
Bae, Nan Young
Gi, Mi Young
Yoon, Hyun
author_sort Seong, Jeong Min
collection PubMed
description BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL). RESULTS: The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456). CONCLUSION: Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women.
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spelling pubmed-54510002017-06-12 Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults Seong, Jeong Min Yoon, Yo Sang Lee, Kyu Su Bae, Nan Young Gi, Mi Young Yoon, Hyun PLoS One Research Article BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL). RESULTS: The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456). CONCLUSION: Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women. Public Library of Science 2017-05-31 /pmc/articles/PMC5451000/ /pubmed/28562685 http://dx.doi.org/10.1371/journal.pone.0177722 Text en © 2017 Seong et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Seong, Jeong Min
Yoon, Yo Sang
Lee, Kyu Su
Bae, Nan Young
Gi, Mi Young
Yoon, Hyun
Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
title Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
title_full Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
title_fullStr Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
title_full_unstemmed Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
title_short Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
title_sort gender difference in relationship between serum ferritin and 25-hydroxyvitamin d in korean adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451000/
https://www.ncbi.nlm.nih.gov/pubmed/28562685
http://dx.doi.org/10.1371/journal.pone.0177722
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