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Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients

BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft damage and loss. The elements of the adaptive immune system that are permissive of reactivation and responsible for viral control remain incompletely described. We performed a prospective study evaluating BKPy...

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Autores principales: DeWolfe, David, Gandhi, Jinal, Mackenzie, Matthew R., Broge, Thomas A., Bord, Evelyn, Babwah, Amaara, Mandelbrot, Didier A., Pavlakis, Martha, Cardarelli, Francesca, Viscidi, Raphael, Chandraker, Anil, Tan, Chen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451008/
https://www.ncbi.nlm.nih.gov/pubmed/28562595
http://dx.doi.org/10.1371/journal.pone.0177339
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author DeWolfe, David
Gandhi, Jinal
Mackenzie, Matthew R.
Broge, Thomas A.
Bord, Evelyn
Babwah, Amaara
Mandelbrot, Didier A.
Pavlakis, Martha
Cardarelli, Francesca
Viscidi, Raphael
Chandraker, Anil
Tan, Chen S.
author_facet DeWolfe, David
Gandhi, Jinal
Mackenzie, Matthew R.
Broge, Thomas A.
Bord, Evelyn
Babwah, Amaara
Mandelbrot, Didier A.
Pavlakis, Martha
Cardarelli, Francesca
Viscidi, Raphael
Chandraker, Anil
Tan, Chen S.
author_sort DeWolfe, David
collection PubMed
description BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft damage and loss. The elements of the adaptive immune system that are permissive of reactivation and responsible for viral control remain incompletely described. We performed a prospective study evaluating BKPyV-specific T-cell response, humoral response and overall T-cell phenotype beginning pre-transplant through one year post-transplant in 28 patients at two centers. We performed an exploratory analysis of risk factors for the development of viremia and viruria as well as compared the immune response to BKPyV in these groups and those who remained BK negative. 6 patients developed viruria and 3 developed viremia. BKPyV-specific CD8(+) T-cells increased post-transplant in viremic and viruric but not BK negative patients. BKPyV-specific CD4(+) T-cells increased in viremic, but not viruric or BK negative patients. Anti-BKPyV IgG antibodies increased in viruric and viremic patients but remained unchanged in BK negative patients. Viremic patients had a greater proportion of CD8(+) effector cells pre-transplant and at 12 months post-transplant. Viremic patients had fewer CD4(+) effector memory cells at 3 months post-transplant. Exploratory analysis demonstrated lower CD4 and higher total CD8 proportions, higher anti-BKPyV antibody titers and the cause of renal failure were associated BKPyV reactivation. In conclusion, low CD4, high CD8 and increased effector CD8 cells were found pre-transplant in patients who became viremic, a phenotype associated with immune senescence. This pre-transplant T-cell senescence phenotype could potentially be used to identify patients at increased risk of BKPyV reactivation.
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spelling pubmed-54510082017-06-12 Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients DeWolfe, David Gandhi, Jinal Mackenzie, Matthew R. Broge, Thomas A. Bord, Evelyn Babwah, Amaara Mandelbrot, Didier A. Pavlakis, Martha Cardarelli, Francesca Viscidi, Raphael Chandraker, Anil Tan, Chen S. PLoS One Research Article BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft damage and loss. The elements of the adaptive immune system that are permissive of reactivation and responsible for viral control remain incompletely described. We performed a prospective study evaluating BKPyV-specific T-cell response, humoral response and overall T-cell phenotype beginning pre-transplant through one year post-transplant in 28 patients at two centers. We performed an exploratory analysis of risk factors for the development of viremia and viruria as well as compared the immune response to BKPyV in these groups and those who remained BK negative. 6 patients developed viruria and 3 developed viremia. BKPyV-specific CD8(+) T-cells increased post-transplant in viremic and viruric but not BK negative patients. BKPyV-specific CD4(+) T-cells increased in viremic, but not viruric or BK negative patients. Anti-BKPyV IgG antibodies increased in viruric and viremic patients but remained unchanged in BK negative patients. Viremic patients had a greater proportion of CD8(+) effector cells pre-transplant and at 12 months post-transplant. Viremic patients had fewer CD4(+) effector memory cells at 3 months post-transplant. Exploratory analysis demonstrated lower CD4 and higher total CD8 proportions, higher anti-BKPyV antibody titers and the cause of renal failure were associated BKPyV reactivation. In conclusion, low CD4, high CD8 and increased effector CD8 cells were found pre-transplant in patients who became viremic, a phenotype associated with immune senescence. This pre-transplant T-cell senescence phenotype could potentially be used to identify patients at increased risk of BKPyV reactivation. Public Library of Science 2017-05-31 /pmc/articles/PMC5451008/ /pubmed/28562595 http://dx.doi.org/10.1371/journal.pone.0177339 Text en © 2017 DeWolfe et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
DeWolfe, David
Gandhi, Jinal
Mackenzie, Matthew R.
Broge, Thomas A.
Bord, Evelyn
Babwah, Amaara
Mandelbrot, Didier A.
Pavlakis, Martha
Cardarelli, Francesca
Viscidi, Raphael
Chandraker, Anil
Tan, Chen S.
Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
title Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
title_full Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
title_fullStr Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
title_full_unstemmed Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
title_short Pre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
title_sort pre-transplant immune factors may be associated with bk polyomavirus reactivation in kidney transplant recipients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451008/
https://www.ncbi.nlm.nih.gov/pubmed/28562595
http://dx.doi.org/10.1371/journal.pone.0177339
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