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The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer
OBJECTIVE: Concentrating on oncogenic role and increased plasma expression of microRNA(miR) 106b~25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated significance of the over-expression of plasma miR 106b~25 in GC. METHODS: Based on 65 pairs matched GC patients and health controls, we e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451054/ https://www.ncbi.nlm.nih.gov/pubmed/28562634 http://dx.doi.org/10.1371/journal.pone.0178427 |
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author | Li, Fangxuan Guo, Yuenan Liu, Juntian Zhang, Rupeng |
author_facet | Li, Fangxuan Guo, Yuenan Liu, Juntian Zhang, Rupeng |
author_sort | Li, Fangxuan |
collection | PubMed |
description | OBJECTIVE: Concentrating on oncogenic role and increased plasma expression of microRNA(miR) 106b~25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated significance of the over-expression of plasma miR 106b~25 in GC. METHODS: Based on 65 pairs matched GC patients and health controls, we explored clinical significance of miR 106b~25 for GC and compared their diagnostic performance with conventional tumor biomarkers including CA724, CA242, CA199 and CEA. RESULTS: Both miR 106b~25 cluster and conventional tumor biomarkers were significantly elevated in GC (All P<0.05). In ROC curves, miR 106b had the highest AUC (0.898) in diagnosing GC with optimal sensitivity of 86.2% and specificity of 92.3% at the cut-off value of 1.385. MiR 25 had moderate diagnostic efficacy (AUC = 0.817) with sensitivity of 87.6% and specificity of 76.9% at the threshold of 1.015. The AUC of miR 93 (0.756) was the lowest. The AUC, sensitivity, accuracy and Youden index of miR 106b were higher than all of four conventional biomarkers, while its specificity is higher than CA242 and CA724. The AUC of miR 25 was also higher than CA724, CA242 and CA199, while AUC of miR 93 was only higher than CA199 and CA724. Compared the diagnostic efficacy via ROC curves, miR 106b was significantly higher diagnostic efficacy than CA724, CA242 and CA199, the diagnostic efficacies of miR 93 and miR 25 were significantly higher than CA199(all P<0.05). CONCLUSIONS: Plasma miR 106b~25 cluster, especially miR 106b, were significantly increased in GC patients and may be hopeful diagnostic biomarkers. |
format | Online Article Text |
id | pubmed-5451054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54510542017-06-12 The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer Li, Fangxuan Guo, Yuenan Liu, Juntian Zhang, Rupeng PLoS One Research Article OBJECTIVE: Concentrating on oncogenic role and increased plasma expression of microRNA(miR) 106b~25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated significance of the over-expression of plasma miR 106b~25 in GC. METHODS: Based on 65 pairs matched GC patients and health controls, we explored clinical significance of miR 106b~25 for GC and compared their diagnostic performance with conventional tumor biomarkers including CA724, CA242, CA199 and CEA. RESULTS: Both miR 106b~25 cluster and conventional tumor biomarkers were significantly elevated in GC (All P<0.05). In ROC curves, miR 106b had the highest AUC (0.898) in diagnosing GC with optimal sensitivity of 86.2% and specificity of 92.3% at the cut-off value of 1.385. MiR 25 had moderate diagnostic efficacy (AUC = 0.817) with sensitivity of 87.6% and specificity of 76.9% at the threshold of 1.015. The AUC of miR 93 (0.756) was the lowest. The AUC, sensitivity, accuracy and Youden index of miR 106b were higher than all of four conventional biomarkers, while its specificity is higher than CA242 and CA724. The AUC of miR 25 was also higher than CA724, CA242 and CA199, while AUC of miR 93 was only higher than CA199 and CA724. Compared the diagnostic efficacy via ROC curves, miR 106b was significantly higher diagnostic efficacy than CA724, CA242 and CA199, the diagnostic efficacies of miR 93 and miR 25 were significantly higher than CA199(all P<0.05). CONCLUSIONS: Plasma miR 106b~25 cluster, especially miR 106b, were significantly increased in GC patients and may be hopeful diagnostic biomarkers. Public Library of Science 2017-05-31 /pmc/articles/PMC5451054/ /pubmed/28562634 http://dx.doi.org/10.1371/journal.pone.0178427 Text en © 2017 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Li, Fangxuan Guo, Yuenan Liu, Juntian Zhang, Rupeng The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer |
title | The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer |
title_full | The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer |
title_fullStr | The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer |
title_full_unstemmed | The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer |
title_short | The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer |
title_sort | significance of elevated plasma expression of microrna 106b~25 clusters in gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451054/ https://www.ncbi.nlm.nih.gov/pubmed/28562634 http://dx.doi.org/10.1371/journal.pone.0178427 |
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