Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression

AIMS: Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs) promote the development of abdominal aortic aneurysm (AAA). Previously, we demonstrated that global Notch1 deficiency prevents the formation of AAA in a mouse model. Herein, we sought to explore the cell-specific...

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Detalles Bibliográficos
Autores principales: Sachdeva, Jaspreet, Mahajan, Advitiya, Cheng, Jeeyun, Baeten, Jeremy T., Lilly, Brenda, Kuivaniemi, Helena, Hans, Chetan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451061/
https://www.ncbi.nlm.nih.gov/pubmed/28562688
http://dx.doi.org/10.1371/journal.pone.0178538

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