Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population

South Africa has a large (∼53 million), ethnically diverse population (black African, Caucasian, Indian/Asian and Mixed ancestry) and a high disease burden (particularly HIV-1 and Mycobacterium tuberculosis). The Mixed ancestry population constitutes ∼9% of the total population and was established ∼...

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Autores principales: Loubser, Shayne, Paximadis, Maria, Tiemessen, Caroline T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland 2017
Materias:
Short Population Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451074/
https://www.ncbi.nlm.nih.gov/pubmed/28438553
http://dx.doi.org/10.1016/j.humimm.2017.04.006
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author Loubser, Shayne
Paximadis, Maria
Tiemessen, Caroline T.
author_facet Loubser, Shayne
Paximadis, Maria
Tiemessen, Caroline T.
author_sort Loubser, Shayne
collection PubMed
description South Africa has a large (∼53 million), ethnically diverse population (black African, Caucasian, Indian/Asian and Mixed ancestry) and a high disease burden (particularly HIV-1 and Mycobacterium tuberculosis). The Mixed ancestry population constitutes ∼9% of the total population and was established ∼365 years ago in the Western Cape region through interracial mixing of black Africans, Europeans and Asians. Admixed populations present unique opportunities to identify genetic factors involved in disease susceptibility. Since HLA genes are important mediators of host immunity, we investigated HLA-A, -B and -C allele and haplotype diversity in 50 healthy, unrelated individuals recruited from the Mixed ancestry population.
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spelling pubmed-54510742017-06-08 Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population Loubser, Shayne Paximadis, Maria Tiemessen, Caroline T. Hum Immunol Short Population Report South Africa has a large (∼53 million), ethnically diverse population (black African, Caucasian, Indian/Asian and Mixed ancestry) and a high disease burden (particularly HIV-1 and Mycobacterium tuberculosis). The Mixed ancestry population constitutes ∼9% of the total population and was established ∼365 years ago in the Western Cape region through interracial mixing of black Africans, Europeans and Asians. Admixed populations present unique opportunities to identify genetic factors involved in disease susceptibility. Since HLA genes are important mediators of host immunity, we investigated HLA-A, -B and -C allele and haplotype diversity in 50 healthy, unrelated individuals recruited from the Mixed ancestry population. Elsevier/North-Holland 2017 /pmc/articles/PMC5451074/ /pubmed/28438553 http://dx.doi.org/10.1016/j.humimm.2017.04.006 Text en © 2017 The Authors. American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Population Report
Loubser, Shayne
Paximadis, Maria
Tiemessen, Caroline T.
Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population
title Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population
title_full Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population
title_fullStr Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population
title_full_unstemmed Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population
title_short Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population
title_sort human leukocyte antigen class i (a, b and c) allele and haplotype variation in a south african mixed ancestry population
topic Short Population Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451074/
https://www.ncbi.nlm.nih.gov/pubmed/28438553
http://dx.doi.org/10.1016/j.humimm.2017.04.006
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