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The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein
The biological function of α-Synuclein has been related to binding to lipids and membranes but these interactions can also mediate α-Synuclein aggregation, which is associated to Parkinson’s disease and other neuropathologies. In brain tissue α-Synuclein is constitutively N-acetylated, a modificatio...
Autores principales: | Ruzafa, David, Hernandez-Gomez, Yuriko S., Bisello, Giovanni, Broersen, Kerensa, Morel, Bertrand, Conejero-Lara, Francisco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451137/ https://www.ncbi.nlm.nih.gov/pubmed/28562630 http://dx.doi.org/10.1371/journal.pone.0178576 |
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