Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1

Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds. In contrast, we found that approximately 25% of all acute myeloid leukemias expressed low or undetectable levels of ALDH1A1...

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Detalles Bibliográficos
Autores principales: Gasparetto, Maura, Pei, Shanshan, Minhajuddin, Mohammad, Khan, Nabilah, Pollyea, Daniel A., Myers, Jason R., Ashton, John M., Becker, Michael W., Vasiliou, Vasilis, Humphries, Keith R., Jordan, Craig T., Smith, Clayton A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451337/
https://www.ncbi.nlm.nih.gov/pubmed/28280079
http://dx.doi.org/10.3324/haematol.2016.159053

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