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Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin

Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3′-untransl...

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Autores principales: Chen, Yingqing, Park, Jeongmin, Joe, Yeonsoo, Park, Hyeok-Jun, Jekal, Seung-Joo, Sato, Daisuke, Hamada, Hiroki, Chung, Hun Taeg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451844/
https://www.ncbi.nlm.nih.gov/pubmed/28607633
http://dx.doi.org/10.1155/2017/9427583
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author Chen, Yingqing
Park, Jeongmin
Joe, Yeonsoo
Park, Hyeok-Jun
Jekal, Seung-Joo
Sato, Daisuke
Hamada, Hiroki
Chung, Hun Taeg
author_facet Chen, Yingqing
Park, Jeongmin
Joe, Yeonsoo
Park, Hyeok-Jun
Jekal, Seung-Joo
Sato, Daisuke
Hamada, Hiroki
Chung, Hun Taeg
author_sort Chen, Yingqing
collection PubMed
description Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3′-untranslated regions of mRNAs. Here, we utilized pterostilbene 4′-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement. TTP expression was increased in 4-PG dose- and time-dependent manners in RAW264.7 cells. The production of proinflammatory cytokine, such as TNF-α, was reduced by 4-PG in vitro. To investigate the role of TTP in the anti-inflammatory effects of 4-PG, we used DSS–induced colitis in TTP WT and KO mice as models. The expression levels of TTP and proinflammatory cytokines were determined in serum and colon tissue. 4-PG increased the expression of TTP while suppressing proinflammatory cytokines both in vitro and in vivo. These findings suggest that treatment with 4-PG mediates the anti-inflammatory effects of 4-PG on DSS-induced colitis via enhancing TTP expression.
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spelling pubmed-54518442017-06-12 Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin Chen, Yingqing Park, Jeongmin Joe, Yeonsoo Park, Hyeok-Jun Jekal, Seung-Joo Sato, Daisuke Hamada, Hiroki Chung, Hun Taeg Oxid Med Cell Longev Research Article Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3′-untranslated regions of mRNAs. Here, we utilized pterostilbene 4′-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement. TTP expression was increased in 4-PG dose- and time-dependent manners in RAW264.7 cells. The production of proinflammatory cytokine, such as TNF-α, was reduced by 4-PG in vitro. To investigate the role of TTP in the anti-inflammatory effects of 4-PG, we used DSS–induced colitis in TTP WT and KO mice as models. The expression levels of TTP and proinflammatory cytokines were determined in serum and colon tissue. 4-PG increased the expression of TTP while suppressing proinflammatory cytokines both in vitro and in vivo. These findings suggest that treatment with 4-PG mediates the anti-inflammatory effects of 4-PG on DSS-induced colitis via enhancing TTP expression. Hindawi 2017 2017-05-07 /pmc/articles/PMC5451844/ /pubmed/28607633 http://dx.doi.org/10.1155/2017/9427583 Text en Copyright © 2017 Yingqing Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Yingqing
Park, Jeongmin
Joe, Yeonsoo
Park, Hyeok-Jun
Jekal, Seung-Joo
Sato, Daisuke
Hamada, Hiroki
Chung, Hun Taeg
Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
title Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
title_full Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
title_fullStr Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
title_full_unstemmed Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
title_short Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
title_sort pterostilbene 4′-β-glucoside protects against dss-induced colitis via induction of tristetraprolin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451844/
https://www.ncbi.nlm.nih.gov/pubmed/28607633
http://dx.doi.org/10.1155/2017/9427583
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