Cargando…

Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children

Nonalcoholic fatty liver disease (NAFLD) has become a serious public health problem worldwide; however, the availability of information on the prevalence of NAFLD in the general pediatric population is still limited. The primary aim of this study was to reveal the prevalence and correlates of suspec...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Peige, Yu, Jinyue, Wang, Manli, Chang, Xinlei, Wang, Jiawen, An, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451916/
https://www.ncbi.nlm.nih.gov/pubmed/28448433
http://dx.doi.org/10.3390/ijerph14050465
_version_ 1783240275075792896
author Song, Peige
Yu, Jinyue
Wang, Manli
Chang, Xinlei
Wang, Jiawen
An, Lin
author_facet Song, Peige
Yu, Jinyue
Wang, Manli
Chang, Xinlei
Wang, Jiawen
An, Lin
author_sort Song, Peige
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) has become a serious public health problem worldwide; however, the availability of information on the prevalence of NAFLD in the general pediatric population is still limited. The primary aim of this study was to reveal the prevalence and correlates of suspected NAFLD in Chinese children at the national level. Data from the China Health and Nutrition Surveys (CHNS) was used. Weight, height, waist circumference (WC), blood pressure (BP) were measured for children aged 7–18 years. Blood samples were collected and analyzed. Children were classified as having suspected NAFLD if common causes of liver disease were excluded, and serum alanine aminotransferase (ALT) values were above the established thresholds (>22.1 IU/L for girls and >25.8 IU/L for boys). A percentage of 9.03% (75 out of 831) of Chinese children was found to have suspected NAFLD. Overweight and obesity according to BMI percentiles, abdominal obesity, hyperuricemia (uric acid (UA) > 327 μmol/L), and elevated total cholesterol (TC) were all detected as the correlates of childhood suspected NAFLD when adjusting for other factors. Our study revealed the prevalence of suspected NAFLD in general Chinese children at the national level for the first time. Our findings indicate that suspected NAFLD in children is associated with increasing childhood morbidities, further studies are needed to better understand the prevalence of childhood NAFLD and its correlates, and large-scale programs should be launched to screen NAFLD in the pediatric population in China.
format Online
Article
Text
id pubmed-5451916
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-54519162017-06-05 Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children Song, Peige Yu, Jinyue Wang, Manli Chang, Xinlei Wang, Jiawen An, Lin Int J Environ Res Public Health Article Nonalcoholic fatty liver disease (NAFLD) has become a serious public health problem worldwide; however, the availability of information on the prevalence of NAFLD in the general pediatric population is still limited. The primary aim of this study was to reveal the prevalence and correlates of suspected NAFLD in Chinese children at the national level. Data from the China Health and Nutrition Surveys (CHNS) was used. Weight, height, waist circumference (WC), blood pressure (BP) were measured for children aged 7–18 years. Blood samples were collected and analyzed. Children were classified as having suspected NAFLD if common causes of liver disease were excluded, and serum alanine aminotransferase (ALT) values were above the established thresholds (>22.1 IU/L for girls and >25.8 IU/L for boys). A percentage of 9.03% (75 out of 831) of Chinese children was found to have suspected NAFLD. Overweight and obesity according to BMI percentiles, abdominal obesity, hyperuricemia (uric acid (UA) > 327 μmol/L), and elevated total cholesterol (TC) were all detected as the correlates of childhood suspected NAFLD when adjusting for other factors. Our study revealed the prevalence of suspected NAFLD in general Chinese children at the national level for the first time. Our findings indicate that suspected NAFLD in children is associated with increasing childhood morbidities, further studies are needed to better understand the prevalence of childhood NAFLD and its correlates, and large-scale programs should be launched to screen NAFLD in the pediatric population in China. MDPI 2017-04-27 2017-05 /pmc/articles/PMC5451916/ /pubmed/28448433 http://dx.doi.org/10.3390/ijerph14050465 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Peige
Yu, Jinyue
Wang, Manli
Chang, Xinlei
Wang, Jiawen
An, Lin
Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children
title Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children
title_full Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children
title_fullStr Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children
title_full_unstemmed Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children
title_short Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children
title_sort prevalence and correlates of suspected nonalcoholic fatty liver disease in chinese children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451916/
https://www.ncbi.nlm.nih.gov/pubmed/28448433
http://dx.doi.org/10.3390/ijerph14050465
work_keys_str_mv AT songpeige prevalenceandcorrelatesofsuspectednonalcoholicfattyliverdiseaseinchinesechildren
AT yujinyue prevalenceandcorrelatesofsuspectednonalcoholicfattyliverdiseaseinchinesechildren
AT wangmanli prevalenceandcorrelatesofsuspectednonalcoholicfattyliverdiseaseinchinesechildren
AT changxinlei prevalenceandcorrelatesofsuspectednonalcoholicfattyliverdiseaseinchinesechildren
AT wangjiawen prevalenceandcorrelatesofsuspectednonalcoholicfattyliverdiseaseinchinesechildren
AT anlin prevalenceandcorrelatesofsuspectednonalcoholicfattyliverdiseaseinchinesechildren