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Chromatin determinants impart camptothecin sensitivity

Camptothecin‐induced locking of topoisomerase 1 on DNA generates a physical barrier to replication fork progression and creates topological stress. By allowing replisome rotation, absence of the Tof1/Csm3 complex promotes the conversion of impending topological stress to DNA catenation and causes ca...

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Detalles Bibliográficos
Autores principales:	Puddu, Fabio, Salguero, Israel, Herzog, Mareike, Geisler, Nicola J, Costanzo, Vincenzo, Jackson, Stephen P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452016/ https://www.ncbi.nlm.nih.gov/pubmed/28389464 http://dx.doi.org/10.15252/embr.201643560

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