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The plant cell cycle: Pre-Replication complex formation and controls

The multiplication of cells in all living organisms requires a tight regulation of DNA replication. Several mechanisms take place to ensure that the DNA is replicated faithfully and just once per cell cycle in order to originate through mitoses two new daughter cells that contain exactly the same in...

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Autores principales: Brasil, Juliana Nogueira, Costa, Carinne N. Monteiro, Cabral, Luiz Mors, Ferreira, Paulo C. G., Hemerly, Adriana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452130/
https://www.ncbi.nlm.nih.gov/pubmed/28304073
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0118
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author Brasil, Juliana Nogueira
Costa, Carinne N. Monteiro
Cabral, Luiz Mors
Ferreira, Paulo C. G.
Hemerly, Adriana S.
author_facet Brasil, Juliana Nogueira
Costa, Carinne N. Monteiro
Cabral, Luiz Mors
Ferreira, Paulo C. G.
Hemerly, Adriana S.
author_sort Brasil, Juliana Nogueira
collection PubMed
description The multiplication of cells in all living organisms requires a tight regulation of DNA replication. Several mechanisms take place to ensure that the DNA is replicated faithfully and just once per cell cycle in order to originate through mitoses two new daughter cells that contain exactly the same information from the previous one. A key control mechanism that occurs before cells enter S phase is the formation of a pre-replication complex (pre-RC) that is assembled at replication origins by the sequential association of the origin recognition complex, followed by Cdt1, Cdc6 and finally MCMs, licensing DNA to start replication. The identification of pre-RC members in all animal and plant species shows that this complex is conserved in eukaryotes and, more importantly, the differences between kingdoms might reflect their divergence in strategies on cell cycle regulation, as it must be integrated and adapted to the niche, ecosystem, and the organism peculiarities. Here, we provide an overview of the knowledge generated so far on the formation and the developmental controls of the pre-RC mechanism in plants, analyzing some particular aspects in comparison to other eukaryotes.
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spelling pubmed-54521302017-06-08 The plant cell cycle: Pre-Replication complex formation and controls Brasil, Juliana Nogueira Costa, Carinne N. Monteiro Cabral, Luiz Mors Ferreira, Paulo C. G. Hemerly, Adriana S. Genet Mol Biol Plant Molecular Biology The multiplication of cells in all living organisms requires a tight regulation of DNA replication. Several mechanisms take place to ensure that the DNA is replicated faithfully and just once per cell cycle in order to originate through mitoses two new daughter cells that contain exactly the same information from the previous one. A key control mechanism that occurs before cells enter S phase is the formation of a pre-replication complex (pre-RC) that is assembled at replication origins by the sequential association of the origin recognition complex, followed by Cdt1, Cdc6 and finally MCMs, licensing DNA to start replication. The identification of pre-RC members in all animal and plant species shows that this complex is conserved in eukaryotes and, more importantly, the differences between kingdoms might reflect their divergence in strategies on cell cycle regulation, as it must be integrated and adapted to the niche, ecosystem, and the organism peculiarities. Here, we provide an overview of the knowledge generated so far on the formation and the developmental controls of the pre-RC mechanism in plants, analyzing some particular aspects in comparison to other eukaryotes. Sociedade Brasileira de Genética 2017-03-16 2017-04 /pmc/articles/PMC5452130/ /pubmed/28304073 http://dx.doi.org/10.1590/1678-4685-GMB-2016-0118 Text en Copyright © 2017, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Plant Molecular Biology
Brasil, Juliana Nogueira
Costa, Carinne N. Monteiro
Cabral, Luiz Mors
Ferreira, Paulo C. G.
Hemerly, Adriana S.
The plant cell cycle: Pre-Replication complex formation and controls
title The plant cell cycle: Pre-Replication complex formation and controls
title_full The plant cell cycle: Pre-Replication complex formation and controls
title_fullStr The plant cell cycle: Pre-Replication complex formation and controls
title_full_unstemmed The plant cell cycle: Pre-Replication complex formation and controls
title_short The plant cell cycle: Pre-Replication complex formation and controls
title_sort plant cell cycle: pre-replication complex formation and controls
topic Plant Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452130/
https://www.ncbi.nlm.nih.gov/pubmed/28304073
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0118
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