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Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial

Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment. Vitamin D supplementation is widely used to prevent and treat musculoskeletal diseases but existing data on vitamin D effects on markers of bone resorption and formation are inco...

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Autores principales: Schwetz, Verena, Trummer, Christian, Pandis, Marlene, Grübler, Martin R., Verheyen, Nicolas, Gaksch, Martin, Zittermann, Armin, März, Winfried, Aberer, Felix, Lang, Angelika, Treiber, Gerlies, Friedl, Claudia, Obermayer-Pietsch, Barbara, Pieber, Thomas R., Tomaschitz, Andreas, Pilz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452162/
https://www.ncbi.nlm.nih.gov/pubmed/28448457
http://dx.doi.org/10.3390/nu9050432
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author Schwetz, Verena
Trummer, Christian
Pandis, Marlene
Grübler, Martin R.
Verheyen, Nicolas
Gaksch, Martin
Zittermann, Armin
März, Winfried
Aberer, Felix
Lang, Angelika
Treiber, Gerlies
Friedl, Claudia
Obermayer-Pietsch, Barbara
Pieber, Thomas R.
Tomaschitz, Andreas
Pilz, Stefan
author_facet Schwetz, Verena
Trummer, Christian
Pandis, Marlene
Grübler, Martin R.
Verheyen, Nicolas
Gaksch, Martin
Zittermann, Armin
März, Winfried
Aberer, Felix
Lang, Angelika
Treiber, Gerlies
Friedl, Claudia
Obermayer-Pietsch, Barbara
Pieber, Thomas R.
Tomaschitz, Andreas
Pilz, Stefan
author_sort Schwetz, Verena
collection PubMed
description Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment. Vitamin D supplementation is widely used to prevent and treat musculoskeletal diseases but existing data on vitamin D effects on markers of bone resorption and formation are inconsistent. We therefore examined the effects of vitamin D supplementation on bone-specific alkaline phosphatase (bALP), osteocalcin (OC), C-terminal telopeptide (CTX), and procollagen type 1 N-terminal propeptide (P1NP). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial, a single-center, double-blind, randomized, placebo-controlled trial (RCT) performed at the Medical University of Graz, Austria (2011–2014). Two hundred individuals with arterial hypertension and 25-hydroxyvitamin D (25[OH]D) levels <75 nmol/L were randomized to 2800 IU of vitamin D daily or placebo for eight weeks. One hundred ninety-seven participants (60.2 ± 11.1 years; 47% women) were included in this analysis. Vitamin D had no significant effect on bALP (mean treatment effect (MTE) 0.013, 95% CI −0.029 to 0.056 µg/L; p = 0.533), CTX (MTE 0.024, 95% CI −0.163 to 0.210 ng/mL, p = 0.802), OC (MTE 0.020, 95% CI −0.062 to 0.103 ng/mL, p = 0.626), or P1NP (MTE −0.021, 95% CI −0.099 to 0.057 ng/mL, p = 0.597). Analyzing patients with 25(OH)D levels <50 nmol/L separately (n = 74) left results largely unchanged. In hypertensive patients with low 25(OH)D levels, we observed no significant effect of vitamin D supplementation for eight weeks on BTMs.
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spelling pubmed-54521622017-06-05 Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial Schwetz, Verena Trummer, Christian Pandis, Marlene Grübler, Martin R. Verheyen, Nicolas Gaksch, Martin Zittermann, Armin März, Winfried Aberer, Felix Lang, Angelika Treiber, Gerlies Friedl, Claudia Obermayer-Pietsch, Barbara Pieber, Thomas R. Tomaschitz, Andreas Pilz, Stefan Nutrients Article Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment. Vitamin D supplementation is widely used to prevent and treat musculoskeletal diseases but existing data on vitamin D effects on markers of bone resorption and formation are inconsistent. We therefore examined the effects of vitamin D supplementation on bone-specific alkaline phosphatase (bALP), osteocalcin (OC), C-terminal telopeptide (CTX), and procollagen type 1 N-terminal propeptide (P1NP). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial, a single-center, double-blind, randomized, placebo-controlled trial (RCT) performed at the Medical University of Graz, Austria (2011–2014). Two hundred individuals with arterial hypertension and 25-hydroxyvitamin D (25[OH]D) levels <75 nmol/L were randomized to 2800 IU of vitamin D daily or placebo for eight weeks. One hundred ninety-seven participants (60.2 ± 11.1 years; 47% women) were included in this analysis. Vitamin D had no significant effect on bALP (mean treatment effect (MTE) 0.013, 95% CI −0.029 to 0.056 µg/L; p = 0.533), CTX (MTE 0.024, 95% CI −0.163 to 0.210 ng/mL, p = 0.802), OC (MTE 0.020, 95% CI −0.062 to 0.103 ng/mL, p = 0.626), or P1NP (MTE −0.021, 95% CI −0.099 to 0.057 ng/mL, p = 0.597). Analyzing patients with 25(OH)D levels <50 nmol/L separately (n = 74) left results largely unchanged. In hypertensive patients with low 25(OH)D levels, we observed no significant effect of vitamin D supplementation for eight weeks on BTMs. MDPI 2017-04-27 /pmc/articles/PMC5452162/ /pubmed/28448457 http://dx.doi.org/10.3390/nu9050432 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schwetz, Verena
Trummer, Christian
Pandis, Marlene
Grübler, Martin R.
Verheyen, Nicolas
Gaksch, Martin
Zittermann, Armin
März, Winfried
Aberer, Felix
Lang, Angelika
Treiber, Gerlies
Friedl, Claudia
Obermayer-Pietsch, Barbara
Pieber, Thomas R.
Tomaschitz, Andreas
Pilz, Stefan
Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial
title Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial
title_full Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial
title_fullStr Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial
title_full_unstemmed Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial
title_short Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial
title_sort effects of vitamin d supplementation on bone turnover markers: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452162/
https://www.ncbi.nlm.nih.gov/pubmed/28448457
http://dx.doi.org/10.3390/nu9050432
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