Cargando…

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Dietary intake is potentially associated with the onset of Crohn’s disease (CD), but evidence from epidemiological studies has remained unclear. This study aimed to evaluate the role of macronutrient intake in the development of CD. A systematic search was conducted in PubMed and Web of Science to i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Lirong, Hu, Sheng, Chen, Pengfei, Wei, Wenbin, Tan, Yuanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452230/
https://www.ncbi.nlm.nih.gov/pubmed/28505133
http://dx.doi.org/10.3390/nu9050500
_version_ 1783240361660907520
author Zeng, Lirong
Hu, Sheng
Chen, Pengfei
Wei, Wenbin
Tan, Yuanzhong
author_facet Zeng, Lirong
Hu, Sheng
Chen, Pengfei
Wei, Wenbin
Tan, Yuanzhong
author_sort Zeng, Lirong
collection PubMed
description Dietary intake is potentially associated with the onset of Crohn’s disease (CD), but evidence from epidemiological studies has remained unclear. This study aimed to evaluate the role of macronutrient intake in the development of CD. A systematic search was conducted in PubMed and Web of Science to identify all relevant studies, and the role of macronutrients in the development of CD was quantitatively assessed by dose–response meta-analysis. Four case-control studies (a total of 311 CD cases and 660 controls) and five prospective cohort studies (238,887 participants and 482 cases) were identified. The pooled relative risks (RR) for per 10 g increment/day were 0.991 (95% confidence interval (CI): 0.978–1.004) for total carbohydrate intake, 1.018 (95% CI: 0.969–1.069) for total fat intake, and 1.029 (95% CI: 0.955–1.109) for total protein intake. Fiber intake was inversely associated with CD risk (RR for per 10 g increment/day: 0.853, 95% CI: 0.762–0.955), but the association was influenced by study design and smoking adjustment. In subtypes, sucrose intake was positively related with CD risk (RR for per 10 g increment/day: 1.088, 95% CI: 1.020–1.160). Non-linear dose–response association was also found between fiber and sucrose intake and CD risk. In conclusion, this meta-analysis suggested a lack of association between total carbohydrate, fat or protein intake and the risk of CD, while high fiber intake might decrease the risk. In subtypes, high sucrose intake might increase the risk of CD.
format Online
Article
Text
id pubmed-5452230
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-54522302017-06-05 Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies Zeng, Lirong Hu, Sheng Chen, Pengfei Wei, Wenbin Tan, Yuanzhong Nutrients Article Dietary intake is potentially associated with the onset of Crohn’s disease (CD), but evidence from epidemiological studies has remained unclear. This study aimed to evaluate the role of macronutrient intake in the development of CD. A systematic search was conducted in PubMed and Web of Science to identify all relevant studies, and the role of macronutrients in the development of CD was quantitatively assessed by dose–response meta-analysis. Four case-control studies (a total of 311 CD cases and 660 controls) and five prospective cohort studies (238,887 participants and 482 cases) were identified. The pooled relative risks (RR) for per 10 g increment/day were 0.991 (95% confidence interval (CI): 0.978–1.004) for total carbohydrate intake, 1.018 (95% CI: 0.969–1.069) for total fat intake, and 1.029 (95% CI: 0.955–1.109) for total protein intake. Fiber intake was inversely associated with CD risk (RR for per 10 g increment/day: 0.853, 95% CI: 0.762–0.955), but the association was influenced by study design and smoking adjustment. In subtypes, sucrose intake was positively related with CD risk (RR for per 10 g increment/day: 1.088, 95% CI: 1.020–1.160). Non-linear dose–response association was also found between fiber and sucrose intake and CD risk. In conclusion, this meta-analysis suggested a lack of association between total carbohydrate, fat or protein intake and the risk of CD, while high fiber intake might decrease the risk. In subtypes, high sucrose intake might increase the risk of CD. MDPI 2017-05-15 /pmc/articles/PMC5452230/ /pubmed/28505133 http://dx.doi.org/10.3390/nu9050500 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zeng, Lirong
Hu, Sheng
Chen, Pengfei
Wei, Wenbin
Tan, Yuanzhong
Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies
title Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies
title_full Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies
title_fullStr Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies
title_full_unstemmed Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies
title_short Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies
title_sort macronutrient intake and risk of crohn’s disease: systematic review and dose–response meta-analysis of epidemiological studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452230/
https://www.ncbi.nlm.nih.gov/pubmed/28505133
http://dx.doi.org/10.3390/nu9050500
work_keys_str_mv AT zenglirong macronutrientintakeandriskofcrohnsdiseasesystematicreviewanddoseresponsemetaanalysisofepidemiologicalstudies
AT husheng macronutrientintakeandriskofcrohnsdiseasesystematicreviewanddoseresponsemetaanalysisofepidemiologicalstudies
AT chenpengfei macronutrientintakeandriskofcrohnsdiseasesystematicreviewanddoseresponsemetaanalysisofepidemiologicalstudies
AT weiwenbin macronutrientintakeandriskofcrohnsdiseasesystematicreviewanddoseresponsemetaanalysisofepidemiologicalstudies
AT tanyuanzhong macronutrientintakeandriskofcrohnsdiseasesystematicreviewanddoseresponsemetaanalysisofepidemiologicalstudies