Cargando…

Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program

Vitamin A (VA) fortification of cooking oil is considered a cost-effective strategy for increasing VA status, but few large-scale programs have been evaluated. We conducted representative surveys in Yaoundé and Douala, Cameroon, 2 years before and 1 year after the introduction of a mandatory nationa...

Descripción completa

Detalles Bibliográficos
Autores principales: Engle-Stone, Reina, Nankap, Martin, Ndjebayi, Alex, Gimou, Marie-Madeleine, Friedman, Avital, Haskell, Marjorie J., Tarini, Ann, Brown, Kenneth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452252/
https://www.ncbi.nlm.nih.gov/pubmed/28531099
http://dx.doi.org/10.3390/nu9050522
_version_ 1783240369251549184
author Engle-Stone, Reina
Nankap, Martin
Ndjebayi, Alex
Gimou, Marie-Madeleine
Friedman, Avital
Haskell, Marjorie J.
Tarini, Ann
Brown, Kenneth H.
author_facet Engle-Stone, Reina
Nankap, Martin
Ndjebayi, Alex
Gimou, Marie-Madeleine
Friedman, Avital
Haskell, Marjorie J.
Tarini, Ann
Brown, Kenneth H.
author_sort Engle-Stone, Reina
collection PubMed
description Vitamin A (VA) fortification of cooking oil is considered a cost-effective strategy for increasing VA status, but few large-scale programs have been evaluated. We conducted representative surveys in Yaoundé and Douala, Cameroon, 2 years before and 1 year after the introduction of a mandatory national program to fortify cooking oil with VA. In each survey, 10 different households were selected within each of the same 30 clusters (n = ~300). Malaria infection and plasma indicators of inflammation and VA (retinol-binding protein, pRBP) status were assessed among women aged 15–49 years and children aged 12–59 months, and casual breast milk samples were collected for VA and fat measurements. Refined oil intake was measured by a food frequency questionnaire, and VA was measured in household oil samples post-fortification. Pre-fortification, low inflammation-adjusted pRBP was common among children (33% <0.83 µmol/L), but not women (2% <0.78 µmol/L). Refined cooking oil was consumed by >80% of participants in the past week. Post-fortification, only 44% of oil samples were fortified, but fortified samples contained VA concentrations close to the target values. Controlling for age, inflammation, and other covariates, there was no difference in the mean pRBP, mean breast milk VA, prevalence of low pRBP, or prevalence of low milk VA between the pre- and post-fortification surveys. The frequency of refined oil intake was not associated with VA status indicators post-fortification. In sum, after a year of cooking oil fortification with VA, we did not detect evidence of increased plasma RBP or milk VA among urban women and preschool children, possibly because less than half of the refined oil was fortified. The enforcement of norms should be strengthened, and the program should be evaluated in other regions where the prevalence of VA deficiency was greater pre-fortification.
format Online
Article
Text
id pubmed-5452252
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-54522522017-06-05 Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program Engle-Stone, Reina Nankap, Martin Ndjebayi, Alex Gimou, Marie-Madeleine Friedman, Avital Haskell, Marjorie J. Tarini, Ann Brown, Kenneth H. Nutrients Article Vitamin A (VA) fortification of cooking oil is considered a cost-effective strategy for increasing VA status, but few large-scale programs have been evaluated. We conducted representative surveys in Yaoundé and Douala, Cameroon, 2 years before and 1 year after the introduction of a mandatory national program to fortify cooking oil with VA. In each survey, 10 different households were selected within each of the same 30 clusters (n = ~300). Malaria infection and plasma indicators of inflammation and VA (retinol-binding protein, pRBP) status were assessed among women aged 15–49 years and children aged 12–59 months, and casual breast milk samples were collected for VA and fat measurements. Refined oil intake was measured by a food frequency questionnaire, and VA was measured in household oil samples post-fortification. Pre-fortification, low inflammation-adjusted pRBP was common among children (33% <0.83 µmol/L), but not women (2% <0.78 µmol/L). Refined cooking oil was consumed by >80% of participants in the past week. Post-fortification, only 44% of oil samples were fortified, but fortified samples contained VA concentrations close to the target values. Controlling for age, inflammation, and other covariates, there was no difference in the mean pRBP, mean breast milk VA, prevalence of low pRBP, or prevalence of low milk VA between the pre- and post-fortification surveys. The frequency of refined oil intake was not associated with VA status indicators post-fortification. In sum, after a year of cooking oil fortification with VA, we did not detect evidence of increased plasma RBP or milk VA among urban women and preschool children, possibly because less than half of the refined oil was fortified. The enforcement of norms should be strengthened, and the program should be evaluated in other regions where the prevalence of VA deficiency was greater pre-fortification. MDPI 2017-05-20 /pmc/articles/PMC5452252/ /pubmed/28531099 http://dx.doi.org/10.3390/nu9050522 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Engle-Stone, Reina
Nankap, Martin
Ndjebayi, Alex
Gimou, Marie-Madeleine
Friedman, Avital
Haskell, Marjorie J.
Tarini, Ann
Brown, Kenneth H.
Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program
title Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program
title_full Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program
title_fullStr Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program
title_full_unstemmed Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program
title_short Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program
title_sort vitamin a status of women and children in yaoundé and douala, cameroon, is unchanged one year after initiation of a national vitamin a oil fortification program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452252/
https://www.ncbi.nlm.nih.gov/pubmed/28531099
http://dx.doi.org/10.3390/nu9050522
work_keys_str_mv AT englestonereina vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT nankapmartin vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT ndjebayialex vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT gimoumariemadeleine vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT friedmanavital vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT haskellmarjoriej vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT tariniann vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram
AT brownkennethh vitaminastatusofwomenandchildreninyaoundeanddoualacameroonisunchangedoneyearafterinitiationofanationalvitaminaoilfortificationprogram