Cargando…
Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine
A major challenge in experimental epilepsy research is to reconcile the effects of anti-epileptic drugs (AEDs) on individual neurons with their network-level actions. Highlighting this difficulty, it is unclear why carbamazepine (CBZ), a frontline AED with a known molecular mechanism, has been repor...
Autores principales: | Morris, Gareth, Leite, Marco, Kullmann, Dimitri M., Pavlov, Ivan, Schorge, Stephanie, Lignani, Gabriele |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452340/ https://www.ncbi.nlm.nih.gov/pubmed/28473648 http://dx.doi.org/10.1523/JNEUROSCI.3697-16.2017 |
Ejemplares similares
-
KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
por: Magloire, Vincent, et al.
Publicado: (2019) -
Chemical–genetic attenuation of focal neocortical seizures
por: Kätzel, Dennis, et al.
Publicado: (2014) -
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
por: Colasante, Gaia, et al.
Publicado: (2020) -
GABAergic Interneurons in Seizures: Investigating Causality With
Optogenetics
por: Magloire, Vincent, et al.
Publicado: (2018) -
Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model
por: Chang, Bao-Luen, et al.
Publicado: (2018)