Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

BACKGROUND: Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficult target...

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Detalles Bibliográficos
Autores principales: Bongard, Robert D., Lepley, Michael, Thakur, Khushabu, Talipov, Marat R., Nayak, Jaladhi, Lipinski, Rachel A. Jones, Bohl, Chris, Sweeney, Noreena, Ramchandran, Ramani, Rathore, Rajendra, Sem, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452347/
https://www.ncbi.nlm.nih.gov/pubmed/28569147
http://dx.doi.org/10.1186/s12858-017-0083-3

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