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When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form

We report the clinical findings and neuropsychological profiles of a sample of patients exhibiting a focal retrograde amnesia (FRA) seen consecutively during the period 1992–2007. The cohort comprised 13 patients, five males, with a mean age of 30 years (range 16–49). They were given a neurologic ex...

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Autores principales: Stracciari, Andrea, Fonti, Cristina, Guarino, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452448/
https://www.ncbi.nlm.nih.gov/pubmed/19641249
http://dx.doi.org/10.3233/BEN-2008-0222
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author Stracciari, Andrea
Fonti, Cristina
Guarino, Maria
author_facet Stracciari, Andrea
Fonti, Cristina
Guarino, Maria
author_sort Stracciari, Andrea
collection PubMed
description We report the clinical findings and neuropsychological profiles of a sample of patients exhibiting a focal retrograde amnesia (FRA) seen consecutively during the period 1992–2007. The cohort comprised 13 patients, five males, with a mean age of 30 years (range 16–49). They were given a neurologic examination, psychiatric interview and formal neuropsychological examination (all but one) during the amnesic phase, underwent neuroimaging, and were followed up for six months to ten years. All presented with an acute amnesia characterized by an impaired recollection of memories predating the acute event, with spared or minimally and transiently affected anterograde memory, thus consistent with FRA. The events triggering FRA varied widely: mild to severe head injury, road accident without head injury, seizure, dissociative fugue, BDZ overdose, posttraumatic headache, syncope, migraine attack, acute distress. The neuropsychological hallmark of FRA was a selective or prominent impairment of autobiographical memory. The defect was often so severe as to cover most or all of the patients' lives and, in some cases, to erase the knowledge of their own identity. Conventional neuroimaging (brain CT and MRI) was unimpressive. Cerebral SPECT/PET disclosed unilateral frontal hypoperfusion in three (two left). All but one patient fully recovered, time of recovery ranging from three days to six months. FRA is a condition reflecting a block of memory function triggered by heterogeneous events, including both physical and psychic insults. Analogies shared with the more frequently encountered and better known condition of transient global amnesia suggests common pathogenetic mechanisms. A tentative nosographic classification of FRA is finally offered.
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spelling pubmed-54524482017-06-14 When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form Stracciari, Andrea Fonti, Cristina Guarino, Maria Behav Neurol Research Article We report the clinical findings and neuropsychological profiles of a sample of patients exhibiting a focal retrograde amnesia (FRA) seen consecutively during the period 1992–2007. The cohort comprised 13 patients, five males, with a mean age of 30 years (range 16–49). They were given a neurologic examination, psychiatric interview and formal neuropsychological examination (all but one) during the amnesic phase, underwent neuroimaging, and were followed up for six months to ten years. All presented with an acute amnesia characterized by an impaired recollection of memories predating the acute event, with spared or minimally and transiently affected anterograde memory, thus consistent with FRA. The events triggering FRA varied widely: mild to severe head injury, road accident without head injury, seizure, dissociative fugue, BDZ overdose, posttraumatic headache, syncope, migraine attack, acute distress. The neuropsychological hallmark of FRA was a selective or prominent impairment of autobiographical memory. The defect was often so severe as to cover most or all of the patients' lives and, in some cases, to erase the knowledge of their own identity. Conventional neuroimaging (brain CT and MRI) was unimpressive. Cerebral SPECT/PET disclosed unilateral frontal hypoperfusion in three (two left). All but one patient fully recovered, time of recovery ranging from three days to six months. FRA is a condition reflecting a block of memory function triggered by heterogeneous events, including both physical and psychic insults. Analogies shared with the more frequently encountered and better known condition of transient global amnesia suggests common pathogenetic mechanisms. A tentative nosographic classification of FRA is finally offered. IOS Press 2008 2009-07-29 /pmc/articles/PMC5452448/ /pubmed/19641249 http://dx.doi.org/10.3233/BEN-2008-0222 Text en Copyright © 2008 Hindawi Publishing Corporation and the authors. http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Stracciari, Andrea
Fonti, Cristina
Guarino, Maria
When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form
title When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form
title_full When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form
title_fullStr When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form
title_full_unstemmed When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form
title_short When the Past is Lost: Focal Retrograde Amnesia. Focus on the“Functional” Form
title_sort when the past is lost: focal retrograde amnesia. focus on the“functional” form
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452448/
https://www.ncbi.nlm.nih.gov/pubmed/19641249
http://dx.doi.org/10.3233/BEN-2008-0222
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