TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

BACKGROUND: Dysregulated transforming growth factor β (TGFβ) signaling is implicated in osteoarthritis development, making normalizing TGFβ signaling a possible therapy. Theoretically, this can be achieved with small molecule inhibitors specifically targeting the various TGFβ receptors and downstrea...

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Detalles Bibliográficos
Autores principales: van Caam, Arjan, Madej, Wojciech, Garcia de Vinuesa, Amaya, Goumans, Marie-José, ten Dijke, Peter, Blaney Davidson, Esmeralda, van der Kraan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452635/
https://www.ncbi.nlm.nih.gov/pubmed/28569204
http://dx.doi.org/10.1186/s13075-017-1302-4

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