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Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma

Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying...

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Autores principales: Yang, Liqun, Huang, Mengying, Tan, Juan, Hou, Jianbing, He, Jiang, Wang, Feng, Cui, Hongjuan, Yi, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453012/
https://www.ncbi.nlm.nih.gov/pubmed/28599430
http://dx.doi.org/10.3892/ol.2017.6030
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author Yang, Liqun
Huang, Mengying
Tan, Juan
Hou, Jianbing
He, Jiang
Wang, Feng
Cui, Hongjuan
Yi, Liang
author_facet Yang, Liqun
Huang, Mengying
Tan, Juan
Hou, Jianbing
He, Jiang
Wang, Feng
Cui, Hongjuan
Yi, Liang
author_sort Yang, Liqun
collection PubMed
description Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by which TAZ controls these cellular processes, the present study used lentivirus expression system, flow cytometry, immunofluorescence and subcutaneous xenograft assays. The present study demonstrated that TAZ promoted and was indispensable for neuroblastoma cell proliferation and tumorigenesis. Additional mechanistic assays revealed that the downregulation of TAZ induced cell cycle arrest in the G1 phase, which may be mediated through the inhibition of cyclin E2 expression. These findings indicated that TAZ may serve as a potential neuroblastoma therapeutic target.
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spelling pubmed-54530122017-06-08 Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma Yang, Liqun Huang, Mengying Tan, Juan Hou, Jianbing He, Jiang Wang, Feng Cui, Hongjuan Yi, Liang Oncol Lett Articles Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by which TAZ controls these cellular processes, the present study used lentivirus expression system, flow cytometry, immunofluorescence and subcutaneous xenograft assays. The present study demonstrated that TAZ promoted and was indispensable for neuroblastoma cell proliferation and tumorigenesis. Additional mechanistic assays revealed that the downregulation of TAZ induced cell cycle arrest in the G1 phase, which may be mediated through the inhibition of cyclin E2 expression. These findings indicated that TAZ may serve as a potential neuroblastoma therapeutic target. D.A. Spandidos 2017-06 2017-04-12 /pmc/articles/PMC5453012/ /pubmed/28599430 http://dx.doi.org/10.3892/ol.2017.6030 Text en Copyright: © Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yang, Liqun
Huang, Mengying
Tan, Juan
Hou, Jianbing
He, Jiang
Wang, Feng
Cui, Hongjuan
Yi, Liang
Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma
title Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma
title_full Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma
title_fullStr Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma
title_full_unstemmed Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma
title_short Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma
title_sort transcriptional co-activator with pdz-binding motif overexpression promotes cell proliferation and transcriptional co-activator with pdz-binding motif deficiency induces cell cycle arrest in neuroblastoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453012/
https://www.ncbi.nlm.nih.gov/pubmed/28599430
http://dx.doi.org/10.3892/ol.2017.6030
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