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DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma
The present study was designed to determine the significance of DNA topoisomerase IIa (TopoIIα) and Ki67 in hepatocellular carcinoma cells (HCCs). The present study included 353 patients with HCC. The association of clinicopathological data with the expression of TopoIIα and Ki67 by immunohistochemi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453054/ https://www.ncbi.nlm.nih.gov/pubmed/28599412 http://dx.doi.org/10.3892/ol.2017.5999 |
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author | Cao, Yi Ke, Ruisheng Wang, Shaohu Zhu, Xu Chen, Jianwei Huang, Chao Jiang, Yi Lv, Lizhi |
author_facet | Cao, Yi Ke, Ruisheng Wang, Shaohu Zhu, Xu Chen, Jianwei Huang, Chao Jiang, Yi Lv, Lizhi |
author_sort | Cao, Yi |
collection | PubMed |
description | The present study was designed to determine the significance of DNA topoisomerase IIa (TopoIIα) and Ki67 in hepatocellular carcinoma cells (HCCs). The present study included 353 patients with HCC. The association of clinicopathological data with the expression of TopoIIα and Ki67 by immunohistochemistry was analyzed by χ(2) test. Cox multivariate proportional hazards regression analysis and Kaplan-Meier analysis were performed with all the variables to derive risk estimates associated with overall survival (OS)/recurrence-free survival (RFS) and to control for confounders. TopoIIα and Ki67 were detected in the nuclei of the tumor cells. With TopoIIα, 35.7% of cells exhibited high expression, which was associated with tumor-node-metastasis stage, tumor size and α-fetoprotein level. With Ki67, 37.1% of cells exhibited high expression, which was associated with tumor-node-metastasis stage, tumor size and α-fetoprotein level. Correlation was identified between the expression level of TopoIIα and Ki67 in HCCs (r=0.444). Multivariate analysis revealed that high TopoIIα expression is a prognostic indicator for RFS [hazard ratio (HR), 2.002; 95% confidence interval (CI), 1.429–2.806] and OS (HR, 2.749; 95% CI, 1.919–3.939), and high Ki67 expression is a prognostic indicator for OS (HR, 1.816; 95% CI, 1.273–2.589). The TopoIIα-low group had a significantly increased RFS rate (55.6 vs. 31.7%) and OS rate (66.5 vs. 23.8%) compared with the TopoIIα-high group. The OS rate was increased in the Ki67-low group compared with the Ki67-high group (67.0 vs. 26.5%). Expression of TopoIIα and Ki67 are independent prognostic factors for survival in HCCs. TopoIIα was positively associated with Ki67 expression. |
format | Online Article Text |
id | pubmed-5453054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54530542017-06-08 DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma Cao, Yi Ke, Ruisheng Wang, Shaohu Zhu, Xu Chen, Jianwei Huang, Chao Jiang, Yi Lv, Lizhi Oncol Lett Articles The present study was designed to determine the significance of DNA topoisomerase IIa (TopoIIα) and Ki67 in hepatocellular carcinoma cells (HCCs). The present study included 353 patients with HCC. The association of clinicopathological data with the expression of TopoIIα and Ki67 by immunohistochemistry was analyzed by χ(2) test. Cox multivariate proportional hazards regression analysis and Kaplan-Meier analysis were performed with all the variables to derive risk estimates associated with overall survival (OS)/recurrence-free survival (RFS) and to control for confounders. TopoIIα and Ki67 were detected in the nuclei of the tumor cells. With TopoIIα, 35.7% of cells exhibited high expression, which was associated with tumor-node-metastasis stage, tumor size and α-fetoprotein level. With Ki67, 37.1% of cells exhibited high expression, which was associated with tumor-node-metastasis stage, tumor size and α-fetoprotein level. Correlation was identified between the expression level of TopoIIα and Ki67 in HCCs (r=0.444). Multivariate analysis revealed that high TopoIIα expression is a prognostic indicator for RFS [hazard ratio (HR), 2.002; 95% confidence interval (CI), 1.429–2.806] and OS (HR, 2.749; 95% CI, 1.919–3.939), and high Ki67 expression is a prognostic indicator for OS (HR, 1.816; 95% CI, 1.273–2.589). The TopoIIα-low group had a significantly increased RFS rate (55.6 vs. 31.7%) and OS rate (66.5 vs. 23.8%) compared with the TopoIIα-high group. The OS rate was increased in the Ki67-low group compared with the Ki67-high group (67.0 vs. 26.5%). Expression of TopoIIα and Ki67 are independent prognostic factors for survival in HCCs. TopoIIα was positively associated with Ki67 expression. D.A. Spandidos 2017-06 2017-04-06 /pmc/articles/PMC5453054/ /pubmed/28599412 http://dx.doi.org/10.3892/ol.2017.5999 Text en Copyright: © Cao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Cao, Yi Ke, Ruisheng Wang, Shaohu Zhu, Xu Chen, Jianwei Huang, Chao Jiang, Yi Lv, Lizhi DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma |
title | DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma |
title_full | DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma |
title_fullStr | DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma |
title_full_unstemmed | DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma |
title_short | DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma |
title_sort | dna topoisomerase iiα and ki67 are prognostic factors in patients with hepatocellular carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453054/ https://www.ncbi.nlm.nih.gov/pubmed/28599412 http://dx.doi.org/10.3892/ol.2017.5999 |
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